SynthesisThorax2006
Association between polymorphism of tumour necrosis factor alpha-308 gene promoter and asthma: a meta-analysis.
Synthesis in Thorax, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 6 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Pooled it
- Association between tumor necrosis factor-α rs1800629 polymorphism and risk of asthma: a meta-analysis.PloS one · 2014Pooled it
- The -308 G/A polymorphism in TNF-α gene is associated with asthma risk: an update by meta-analysis.Journal of clinical immunology · 2011Pooled it
- Effect of tumor necrosis factor-α antagonism in asthma: a meta-analysis of the published literature.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2011Pooled it
- The -159C/T polymorphism in the CD14 gene and the risk of asthma: a meta-analysis.Immunogenetics · 2011Pooled it
- Asthma susceptible genes in Chinese population: a meta-analysis.Respiratory research · 2010Pooled it
- Linkage disequilibrium with predisposing DR3 haplotypes accounts for apparent effects of tumor necrosis factor and lymphotoxin-alpha polymorphisms on type 1 diabetes susceptibility.Human immunology · 2006Trial
- Cytokines in sensitization to aeroallergens.Allergologie select · 2018Review
- DNA repair gene XRCC1 polymorphisms and susceptibility to childhood acute lymphoblastic leukemia: a meta-analysis.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2013Article
- CD14 C-159T polymorphism and its association with chronic lung diseases: A pilot study on isocyanate exposed population of Central India.Indian journal of human genetics · 2013Article
- Tumor necrosis factor alpha 308 G/A polymorphism and Guillain-Barré syndrome risk.Molecular biology reports · 2012Article
- Tumour necrosis factor gene polymorphism and disease prevalence.Scandinavian journal of immunology · 2011Review
- Association of TLR-4 and TNF-alpha polymorphisms with clinical symptoms and cytokine levels in patients with allergic rhinitis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2011Article
- Association of the tumor necrosis factor-alpha -308 G/A polymorphism with nasal polyposis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2010Article
- Proinflammatory cytokine gene polymorphisms among Iranian patients with asthma.Journal of clinical immunology · 2009Article
- Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease.Environmental health perspectives · 2008Article
- Influence of genetic factors on toluene diisocyanate-related symptoms: evidence from a cross-sectional study.Environmental health : a global access science source · 2008Article
- IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency.American journal of respiratory cell and molecular biology · 2008Article
- Parental smoking modifies the relation between genetic variation in tumor necrosis factor-alpha (TNF) and childhood asthma.Environmental health perspectives · 2007Article
- Multilocus analysis of atopy in Korean children using multifactor-dimensionality reduction.Thorax · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAsthma is a complex polygenic disease in which gene-environment interactions are important. The gene encoding tumour necrosis factor alpha (TNFalpha) is one of several candidate loci for asthma pathogenesis and is highly polymorphic. A number of studies have investigated the polymorphism of TNFalpha-308 gene promoter (substitution G-->A, designated as TNF1 and TNF2) in relation to asthma susceptibility in different populations. However, the results of individual studies have been inconsistent.
methodsTo address the inconsistent findings in studies of the association of the polymorphism of TNFalpha-308 gene promoter with susceptibility to asthma, a systematic review was undertaken of the published data and a meta-analysis was performed. The MEDLINE database was searched for case-control studies published in English language journals from 1966 to October 2005. Data were extracted using standardised forms and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.
resultsFifteen eligible studies, comprising 2409 patients with asthma and 3266 controls, were included in the meta-analysis. Using the random effects model, the pooled result showed that the TNF2 allele is associated with overall susceptibility to asthma (OR 1.37, 95% CI 1.02 to 1.84, p=0.04). The ORs for asthma susceptibility in TNF2 homozygote individuals were significantly increased at 2.01 (95% CI 1.26 to 3.20, p=0.009) and 1.51 (95% CI 1.02 to 2.22, p=0.041) compared with TNF1 homozygotes and TNF2/1 heterozygotes, respectively. In addition, the pooled OR for asthma risk in TNF2/1 heterozygotes was also significantly higher than that in TNF1/1 homozygotes (OR 1.47, 95% CI 1.01 to 2.13, p=0.045).
conclusionsThe TNF2 allele confers a significant risk for developing asthma. A large scale case-control study is needed to clarify the functional effect of the polymorphism of the TNFalpha gene in the pathogenesis of asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.