Evidence map›Paper›PMID 16517572›Full record

Trial reportThorax2006

Double blind randomised controlled trial of two different breathing techniques in the management of asthma.

C A Slader, H K Reddel, L M Spencer, E G Belousova, C L Armour, S Z Bosnic-Anticevich, F C K Thien, C R Jenkins

Registry-linked trialOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Thorax, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05593315 (Efficacy of the Combination of General Relaxation), which is not on this map. Cited by 14 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 4 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05593315 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Efficacy of the Combination of General Relaxation (Mindfulness) and Respiratory (Buteyko) Techniques for the Improvement of Poorly Controlled Asthma. The MBA Study

TypeinterventionalSponsorFundació Institut de Recerca de l'Hospital de la Santa Creu i Sant PauRan2023 to 2025Enrolled40ConditionsAsthma, Anxiety, StressArmsMindfulness and Buteyko techniques
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 4 syntheses or guidelines pooled it, 99 citations in OpenAlex.

  1. Breathing techniques to reduce symptoms in people with serious respiratory illness: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2024
    Pooled it
  2. Breathing exercises for adults with asthma.The Cochrane database of systematic reviews · 2020
    Pooled it
  3. Pooled it
  4. Home-based educational interventions for children with asthma.The Cochrane database of systematic reviews · 2011
    Pooled it
  5. Trial
  6. Trial
  7. Review
  8. Questions in Mild Asthma: An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2023
    Article
  9. Article
  10. Hypoventilation training for asthma: a case illustration.Applied psychophysiology and biofeedback · 2012
    Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

C A SladerFaculty of Pharmacy, University of Sydney, New South Wales, Australia 2006. cassandra@pharm.usyd.edu.au
H K Reddel
L M Spencer
E G Belousova
C L Armour
S Z Bosnic-Anticevich
F C K Thien
C R Jenkins
UNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies have shown that breathing techniques reduce short acting beta(2) agonist use and improve quality of life (QoL) in asthma. The primary aim of this double blind study was to compare the effects of breathing exercises focusing on shallow nasal breathing with those of non-specific upper body exercises on asthma symptoms, QoL, other measures of disease control, and inhaled corticosteroid (ICS) dose. This study also assessed the effect of peak flow monitoring on outcomes in patients using breathing techniques.

methodsAfter a 2 week run in period, 57 subjects were randomised to one of two breathing techniques learned from instructional videos. During the following 30 weeks subjects practised their exercises twice daily and as needed for relief of symptoms. After week 16, two successive ICS downtitration steps were attempted. The primary outcome variables were QoL score and daily symptom score at week 12.

resultsOverall there were no clinically important differences between the groups in primary or secondary outcomes at weeks 12 or 28. The QoL score remained unchanged (0.7 at baseline v 0.5 at week 28, p = 0.11 both groups combined), as did lung function and airway responsiveness. However, across both groups, reliever use decreased by 86% (p<0.0001) and ICS dose was reduced by 50% (p<0.0001; p>0.10 between groups). Peak flow monitoring did not have a detrimental effect on asthma outcomes.

conclusionBreathing techniques may be useful in the management of patients with mild asthma symptoms who use a reliever frequently, but there is no evidence to favour shallow nasal breathing over non-specific upper body exercises.

Indexed as

Breathing ExercisesAdministration, InhalationAdrenal Cortex HormonesAnti-Asthmatic AgentsAsthmaDouble-Blind MethodFemaleForced Expiratory VolumeHumansMaleQuality of LifeTreatment OutcomeVital CapacityAdrenal Cortex HormonesAnti-Asthmatic Agents

Identifiers

PMID16517572
PMCPMC2104698
OpenAlexW2100594841

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.