ArticleThorax2006
Pathogenic bacteria and viruses in induced sputum or pharyngeal secretions of adults with stable asthma.
Article in Thorax, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06286007 (Prevalence and Impact of Pertussis and RSV on Asthma Severity and Control), which is not on this map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevalence and Impact of Pertussis and RSV on Asthma Severity and Control
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Prevalence of respiratory viruses in stable and acute asthma: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Chlamydia pneumoniae and chronic asthma: Updated systematic review and meta-analysis of population attributable risk.PloS one · 2021Pooled it
- Hidden in plain sight: the impact of human rhinovirus infection in adults.Respiratory research · 2025Review
- A single dose of angiotensin-(1-7) resolves eosinophilic inflammation and protects the lungs from a secondary inflammatory challenge.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Article
- Estimating the pertussis burden in adolescents and adults in the United States between 2007 and 2019.Human vaccines & immunotherapeutics · 2023Article
- Article
- Effects of COVID-19 and Social Distancing on Rhinovirus Infections and Asthma Exacerbations.Viruses · 2022Review
- Pertussis in Individuals with Co-morbidities: A Systematic Review.Infectious diseases and therapy · 2021Review
- Impaired interferon-α expression in plasmacytoid dendritic cells in asthma.Immunity, inflammation and disease · 2021Article
- Pertussis in high-risk groups: an overview of the past quarter-century.Human vaccines & immunotherapeutics · 2020Review
- Impact of community respiratory viral infections in urban children with asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2019Article
- The profile of respiratory pathogens in induced sputum of elderly and non-elderly asthmatics.Central-European journal of immunology · 2019Article
- Review
- Non-specific Effects of Live Attenuated Pertussis Vaccine Against Heterologous Infectious and Inflammatory Diseases.Frontiers in immunology · 2018Review
- Impact of viral infection on acute exacerbation of asthma in out-patient clinics: a prospective study.Journal of thoracic disease · 2016Article
- Detection of respiratory viruses in sputum from adults by use of automated multiplex PCR.Journal of clinical microbiology · 2014Article
- The pharmacological approach to the elderly COPD patient.Drugs & aging · 2013Review
- Rhinovirus-Induced Exacerbations of Asthma and COPD.Scientifica · 2013Review
- Yield of sputum for viral detection by reverse transcriptase PCR in adults hospitalized with respiratory illness.Journal of clinical microbiology · 2012Article
- Repeated virus identification in the airways of patients with mild and severe asthma during prospective follow-up.Allergy · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRespiratory infections are well known triggers of asthma exacerbations, but their role in stable adult asthma remains unclear.
methods103 asthmatics and 30 control subjects were enrolled in the study. Sputum was induced by inhalation of 3% NaCl solution. Oropharyngeal swab specimens were obtained from the posterior wall of the oropharynx. Respiratory specimens were analysed by RT-PCR for rhinovirus, enterovirus and respiratory syncytial virus and by PCR for adenovirus, Chlamydia pneumoniae, Mycoplasma pneumoniae and Bordetella pertussis.
resultsSputum samples from two of the 30 healthy controls (6.7%), five of 53 patients with mild asthma (9.4%), and eight of 50 with moderate asthma (16.0%) were positive for rhinovirus. Rhinovirus positive asthmatic subjects had more asthma symptoms and lower forced expiratory volume in 1 second (FEV(1)) (79% predicted) than rhinovirus negative cases (93.5% predicted; p = 0.020). Chlamydia pneumoniae PCR was positive in 11 healthy controls (36.6%), 11 mild asthmatics (20.8%), and 11 moderate asthmatics (22%), and PCR positive asthmatics had lower FEV(1)/FVC than negative cases (78.2% v 80.8%, p = 0.023). Bordetella pertussis PCR was positive in 30 cases: five healthy controls (16.7%), 15 mild asthmatics (28.3%), and 10 moderate asthmatics (20%). Bordetella pertussis positive individuals had lower FEV(1)/FVC (77.1% v 80.7%, p = 0.012) and more asthma symptoms than B pertussis negative cases.
conclusionsRhinovirus, C pneumoniae, and B pertussis are found in the sputum or pharyngeal swab specimens of asthmatic subjects without concurrent symptoms of infection or asthma exacerbation, as well as in some healthy controls. Positivity is associated with lower lung function and more frequent asthma symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.