Evidence map›Paper›PMID 16517548›Full record

Trial reportBMJ (Clinical research ed.)2006

Rate of over-diagnosis of breast cancer 15 years after end of Malmö mammographic screening trial: follow-up study.

Sophia Zackrisson, Ingvar Andersson, Lars Janzon, Jonas Manjer, Jens Peter Garne

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ (Clinical research ed.), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  3. Recommendations on screening for breast cancer in women aged 40-74 years who are not at increased risk for breast cancer.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2018
    Guideline
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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Sophia ZackrissonDepartment of Clinical Sciences in Malmö, Epidemiological Research Group, Lund University, Malmö University Hospital, SE-205 02, Malmö, Sweden. sophia.zackrisson@med.lu.se
Ingvar Andersson
Lars Janzon
Jonas Manjer
Jens Peter Garne

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the rate of over-diagnosis of breast cancer 15 years after the end of the Malmö mammographic screening trial.

designFollow-up study.

settingMalmö, Sweden. SUBJECTS: 42 283 women aged 45-69 years at randomisation.

interventionsScreening for breast cancer with mammography or not (controls). Screening was offered at the end of the randomisation design to both groups aged 45-54 at randomisation but not to groups aged 55-69 at randomisation.

main outcome measuresRate of over-diagnosis of breast cancer (in situ and invasive), calculated as incidence in the invited and control groups, during period of randomised design (period 1), during period after randomised design ended (period 2), and at end of follow-up.

resultsIn women aged 55-69 years at randomisation the relative rates of over-diagnosis of breast cancer (95% confidence intervals) were 1.32 (1.14 to 1.53) for period 1, 0.92 (0.79 to 1.06) for period 2, and 1.10 (0.99 to 1.22) at the end of follow-up.

conclusionConclusions on over-diagnosis of breast cancer in the Malmö mammographic screening trial can be drawn mainly for women aged 55-69 years at randomisation whose control groups were never screened. Fifteen years after the trial ended the rate of over-diagnosis of breast cancer was 10% in this age group.

Indexed as

AgedAge FactorsBreast NeoplasmsDiagnostic ErrorsFemaleFollow-Up StudiesHumansIncidenceMammographyMass ScreeningMiddle AgedSweden

Identifiers

PMID16517548
PMCPMC1410836

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.