ArticleMolecular and cellular probes
Sentinel-base DNA genotyping using multiple sequencing primers for high-risk human papillomaviruses.
Article in Molecular and cellular probes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Article
- Evaluation of ProExC as a prognostic marker in oropharyngeal squamous cell carcinomas.The American journal of surgical pathology · 2012Article
- Template tailoring: Accurate determination of heterozygous alleles using peptide nucleic acid and dideoxyNTP.Electrophoresis · 2010Article
- Peptide nucleic acid-based array for detecting and genotyping human papillomaviruses.Journal of clinical microbiology · 2009Article
- Article
- Giant magnetoresistive biochip for DNA detection and HPV genotyping.Biosensors & bioelectronics · 2008Article
- Human papillomavirus genotyping by multiplex pyrosequencing in cervical cancer patients from India.Journal of biosciences · 2008Article
- Connector inversion probe technology: a powerful one-primer multiplex DNA amplification system for numerous scientific applications.PloS one · 2007Article
- Does HPV-status 6-12 months after treatment of high grade dysplasia in the uterine cervix predict long term recurrence?European journal of cancer (Oxford, England : 1990) · 2007Article
- PathogenMip assay: a multiplex pathogen detection assay.PloS one · 2007Article
- Article
- PathogenMIPer: a tool for the design of molecular inversion probes to detect multiple pathogens.BMC bioinformatics · 2006Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Despite the various technologies in place for genotyping human papillomaviruses (HPV), clinical use and clinical research demand a method that is fast, more reliable and cost-effective. The technology described here represents a breakthrough development in that direction. By combining the method of multiple sequencing primers with DNA sequencing, we have developed a rapid assay for genotyping HPV that relies on the identification of a single, type-specific 'sentinel' base. As described here, the prototype assay has been developed to recognize the 12 most high-risk HPV types (HPV-16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58 and 59) and is capable of recognizing and simultaneously genotyping multiple HPV co-infections. By providing sequence information on multiple HPV infections, this method eliminates the need for labor- and cost-intensive PCR cloning. These proof-of-concept studies establish the assay to be accurate, reliable, rapid, flexible, and cost-effective, providing evidence of the feasibility this technique for use in clinical settings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.