ReviewCurrent rheumatology reports2006
New thoughts on the pathophysiology of osteoarthritis: one more step toward new therapeutic targets.
Review in Current rheumatology reports, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system.BMC musculoskeletal disorders · 2008Pooled it
- The effect of doxycycline on canine hip osteoarthritis: design of a 6-months clinical trial.Journal of veterinary science · 2009Trial
- Trehalose as an anti-inflammatory agent: insights into molecular mechanisms and therapeutic applications.Inflammopharmacology · 2026Review
- RNA Modifications in Osteoarthritis: Epitranscriptomic Insights into Pathogenesis and Therapeutic Targets.International journal of molecular sciences · 2025Review
- Physiotherapeutic Strategies and Their Current Evidence for Canine Osteoarthritis.Veterinary sciences · 2022Review
- Divergent Mononuclear Cell Participation and Cytokine Release Profiles Define Hip and Knee Osteoarthritis.Journal of clinical medicine · 2019Article
- Schisandrae Fructus ethanol extract ameliorates inflammatory responses and articular cartilage damage in monosodium iodoacetate-induced osteoarthritis in rats.EXCLI journal · 2017Article
- Consequences of metabolic and oxidative modifications of cartilage tissue.Nature reviews. Rheumatology · 2015Review
- Meniscal extrusion or subchondral damage characterize incident accelerated osteoarthritis: Data from the Osteoarthritis Initiative.Clinical anatomy (New York, N.Y.) · 2015Observational
- Phospholipases of mineralization competent cells and matrix vesicles: roles in physiological and pathological mineralizations.International journal of molecular sciences · 2013Article
- Osteoarthritis classification using self organizing map based on gabor kernel and contrast-limited adaptive histogram equalization.The open biomedical engineering journal · 2013Article
- Role of interleukin-1 inhibitors in osteoarthritis: an evidence-based review.Drugs & aging · 2012Review
- Effects of exercise and physical activity on knee osteoarthritis.Current pain and headache reports · 2011Review
- Leptin receptor JAK2/STAT3 signaling modulates expression of Frizzled receptors in articular chondrocytes.Osteoarthritis and cartilage · 2010Article
- Is osteoarthritis a heterogeneous disease that can be stratified into subsets?Clinical rheumatology · 2010Review
- In situ measurement of transport between subchondral bone and articular cartilage.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2009Article
- Osteoid osteoma of the scaphoid presenting with radiocarpal arthritis: a case report.Hand (New York, N.Y.) · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoarthritis is considered an illness in which a complex interaction between the tissues of the joint plays a significant role in the initiation and/or progression of this pathophysiology. We do not yet completely understand all the factors that are responsible for initiating the degradation and loss of the articular tissues. This paper summarizes the novelties of three such mechanisms. The first one points to some factors involved in the regulation of one growth factor family, the bone morphogenetic proteins, the second, the regulation of prostaglandin E(2) synthesis, and the third the factors involved in subchondral bone remodeling, all of which could be very significant events for osteoarthritis. This paper should help the reader better understand the most recent advances regarding the roles of these factors in this disease process, and how new therapeutic targets may be identified.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.