ReviewExpert reviews in molecular medicine2006
DNA-damage response pathways triggered by viral replication.
Review in Expert reviews in molecular medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Evidence of centromeric histone 3 chaperone involved in DNA damage repair pathway in budding yeast.eLife · 2025Article
- Review
- Article
- Flt3L and GM-CSF enhance anti-tumor effect of HPV16/18 vaccine via increasing immune response.American journal of translational research · 2020Article
- Combination Therapy with Reovirus and ATM Inhibitor Enhances Cell Death and Virus Replication in Canine Melanoma.Molecular therapy oncolytics · 2019Article
- Establishment of a nasopharyngeal carcinoma cell line capable of undergoing lytic Epstein-Barr virus reactivation.Laboratory investigation; a journal of technical methods and pathology · 2018Article
- Induction of DNA Damages upon Marek's Disease Virus Infection: Implication in Viral Replication and Pathogenesis.Journal of virology · 2017Article
- The DNA damage response promotes polyomavirus JC infection by nucleus to cytoplasm NF- kappaB activation.Virology journal · 2017Article
- Role of ATM in the formation of the replication compartment during lytic replication of Epstein-Barr virus in nasopharyngeal epithelial cells.Journal of virology · 2015Article
- Simian virus 40 large T antigen induces IFN-stimulated genes through ATR kinase.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- The DNA Damage Response: A Common Pathway in the Regulation of NKG2D and DNAM-1 Ligand Expression in Normal, Infected, and Cancer Cells.Frontiers in immunology · 2014Review
- The modulation of the cell-cycle: a sentinel to alert the NK cells of dangers.Frontiers in immunology · 2013Review
- LEDGF (p75) promotes DNA-end resection and homologous recombination.Nature structural & molecular biology · 2012Article
- The DNA damage response induces IFN.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR.Cell cycle (Georgetown, Tex.) · 2011Article
- Parvovirus B19 nonstructural protein-induced damage of cellular DNA and resultant apoptosis.International journal of medical sciences · 2011Article
- Human cytomegalovirus UL76 induces chromosome aberrations.Journal of biomedical science · 2009Article
- Functional interaction between Epstein-Barr virus replication protein Zta and host DNA damage response protein 53BP1.Journal of virology · 2009Article
- Never-in-mitosis related kinase 1 functions in DNA damage response and checkpoint control.Cell cycle (Georgetown, Tex.) · 2008Article
- Induction of apoptosis limits cytomegalovirus cross-species infection.The EMBO journal · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Many viruses, with distinct replication strategies, activate DNA-damage response pathways, including the lentivirus human immunodeficiency virus (HIV) and the DNA viruses Epstein-Barr virus (EBV), herpes simplex virus 1, adenovirus and SV40. DNA-damage response pathways involving DNA-dependent protein kinase, ataxia-telengiectasia mutated (ATM) and 'ataxia-telengiectasia and Rad3-related' (ATR) have all been implicated. This review focuses on the effects of HIV and EBV replication on DNA repair pathways. It has been suggested that activation of cellular DNA repair and recombination enzymes is beneficial for viral replication, as illustrated by the ability of suppressors of the ATM and ATR family to inhibit HIV replication. However, activation of DNA-damage response pathways can also promote apoptosis. Viruses can tailor the cellular response by suppressing downstream signalling from DNA-damage sensors, as exemplified by EBV. New small-molecule inhibitors of the DNA-damage response pathways could therefore be of value to treat viral infections.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.