ArticleBiophysical journal2006
Cholesterol effect on the dipole potential of lipid membranes.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- The effect of early and intensive statin therapy on ventricular premature beat or nonsustained ventricular tachycardia in patients with acute coronary syndrome.Clinical cardiology · 2011Trial
- Peptide-Assisted Membrane Permeabilization: Effects of Waveform Polarity, Inter-Monopulse Interval, and Surface Charge in Red Blood Cells and Planar Lipid Bilayers.The Journal of membrane biology · 2026Article
- Dipole Potential of Monolayers with Biologically Relevant Lipid Compositions.Molecules (Basel, Switzerland) · 2024Article
- Influence of cholesterol on kinetic parameters for human aromatase (P450 19A1) in phospholipid nanodiscs.Journal of inorganic biochemistry · 2023Article
- Simulating the Voltage-Dependent Fluorescence of Di-8-ANEPPS in a Lipid Membrane.The journal of physical chemistry letters · 2023Article
- Effect of Local Anesthetics on Dipole Potential of Different Phase Membranes: A Fluorescence Study.The Journal of membrane biology · 2022Article
- Phosphodiesterase Type 5 Inhibitors Greatly Affect Physicochemical Properties of Model Lipid Membranes.Membranes · 2021Article
- Single-molecule fluorescence vistas of how lipids regulate membrane proteins.Biochemical Society transactions · 2021Review
- C-Glucosylation as a tool for the prevention of PAINS-induced membrane dipole potential alterations.Scientific reports · 2021Article
- An ω-3, but Not an ω-6 Polyunsaturated Fatty Acid Decreases Membrane Dipole Potential and Stimulates Endo-Lysosomal Escape of Penetratin.Frontiers in cell and developmental biology · 2021Article
- Dexibuprofen Biodegradable Nanoparticles: One Step Closer towards a Better Ocular Interaction Study.Nanomaterials (Basel, Switzerland) · 2020Article
- Alkaloids Modulate the Functioning of Ion Channels Produced by Antimicrobial Agents via an Influence on the Lipid Host.Frontiers in cell and developmental biology · 2020Article
- PMP22 Regulates Cholesterol Trafficking and ABCA1-Mediated Cholesterol Efflux.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Cholesterol depletion inhibits NaThe Journal of biological chemistry · 2019Article
- Polar Interactions Play an Important Role in the Energetics of the Main Phase Transition of Phosphatidylcholine Membranes.ACS omega · 2019Article
- Stereospecific Interactions of Cholesterol in a Model Cell Membrane: Implications for the Membrane Dipole Potential.The Journal of membrane biology · 2018Article
- Liposomal Form of Tetra(Aryl)Tetracyanoporphyrazine: Physical Properties and Photodynamic Activity In Vitro.Journal of fluorescence · 2018Article
- Azole resistance in aThe Journal of biological chemistry · 2018Article
- Assessing anesthetic activity through modulation of the membrane dipole potential.Journal of lipid research · 2017Article
- Differential Membrane Dipolar Orientation Induced by Acute and Chronic Cholesterol Depletion.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of cholesterol removal by methyl-beta-cyclodextrin on the dipole potential, psi(d), of membrane vesicles composed of natural membrane lipids extracted from the kidney and brain of eight vertebrate species was investigated using the voltage-sensitive fluorescent probe di-8-ANEPPS. Cyclodextrin treatment reduced cholesterol levels by on average 80% and this was associated with an average reduction in psi(d) of 50 mV. Measurements of the effect of a range of cholesterol derivatives on the psi(d) of DMPC lipid vesicles showed that the magnitude of the effect correlated with the component of the sterol's dipole moment perpendicular to the membrane surface. The changes in psi(d) observed could not be accounted for solely by the electric field originating from the sterols' dipole moments. Additional factors must arise from sterol-induced changes in lipid packing, which changes the density of dipoles in the membrane, and changes in water penetration into the membrane, which changes the effective dielectric constant of the interfacial region. In DMPC membranes, the cholesterol-induced change in psi(d) was biphasic, i.e., a maximum in psi(d) was observed at approximately 35-45 mol %, after which psi(d) started to decrease. We suggest that this could be associated with a maximum in the strength of DMPC-cholesterol intermolecular forces at this composition.
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