ArticleJournal of bacteriology2006
Abundance of the delta subunit of RNA polymerase is linked to the virulence of Streptococcus agalactiae.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- RpoE-mediated virulence attenuation elicits protective immunity in hypervirulentEmerging microbes & infections · 2026Article
- Multiple factors regulate the expression ofFrontiers in cellular and infection microbiology · 2024Article
- Convergent views on disordered protein dynamics from NMR and computational approaches.Biophysical journal · 2022Article
- The benefits, limitations and opportunities of preclinical models for neonatal drug development.Disease models & mechanisms · 2022Review
- A Novel Function of δ Factor from Bacillus subtilis as a Transcriptional Repressor.The Journal of biological chemistry · 2016Article
- Kinase Inhibitors that Increase the Sensitivity of Methicillin Resistant Staphylococcus aureus to β-Lactam Antibiotics.Pathogens (Basel, Switzerland) · 2015Article
- Small things considered: the small accessory subunits of RNA polymerase in Gram-positive bacteria.FEMS microbiology reviews · 2015Review
- Transcription of Oxidative Stress Genes Is Directly Activated by SpxA1 and, to a Lesser Extent, by SpxA2 in Streptococcus mutans.Journal of bacteriology · 2015Article
- Transcriptional and Phenotypic Characterization of Novel Spx-Regulated Genes in Streptococcus mutans.PloS one · 2015Article
- Temperature-dependent expression of virulence genes in fish-pathogenic bacteria.Frontiers in microbiology · 2015Review
- The δ subunit of RNA polymerase guides promoter selectivity and virulence in Staphylococcus aureus.Infection and immunity · 2014Article
- The δ subunit of RNA polymerase is required for rapid changes in gene expression and competitive fitness of the cell.Journal of bacteriology · 2013Article
- Differential localization of the streptococcal accessory sec components and implications for substrate export.Journal of bacteriology · 2013Article
- Global transcriptome analysis of Lactococcus garvieae strains in response to temperature.PloS one · 2013Article
- Asp2 and Asp3 interact directly with GspB, the export substrate of the Streptococcus gordonii accessory Sec System.Journal of bacteriology · 2011Article
- 5D 13C-detected experiments for backbone assignment of unstructured proteins with a very low signal dispersion.Journal of biomolecular NMR · 2011Article
- Lack of the delta subunit of RNA polymerase increases virulence related traits of Streptococcus mutans.PloS one · 2011Article
- The delta subunit of RNA polymerase, RpoE, is a global modulator of Streptococcus mutans environmental adaptation.Journal of bacteriology · 2010Article
- Regulation of CovR expression in Group B Streptococcus impacts blood-brain barrier penetration.Molecular microbiology · 2010Article
- Identification of serine/threonine kinase substrates in the human pathogen group B streptococcus.Journal of proteome research · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Group B streptococcus (GBS) remains a major cause of morbidity and mortality among newborn children. The bacterium is a commensal organism colonizing the rectum and the gastrointestinal and urogenital tracts of adults, but it can be transmitted to neonates by an ascending infection of the maternal genital tract or during parturition. We previously reported that a transposon insertion disrupting rpoE resulted in the decreased survival of the mutant in the neonatal rat sepsis model of GBS infection. rpoE encodes the delta protein, a subunit of RNA polymerase (RNAP) that has been characterized in Bacillus species. In this study, we confirm the association of the delta protein with purified GBS RNAP and show that it is expressed in strains representing all nine serotypes. Flow cytometric analysis of a reporter strain containing a transcriptional fusion of the rpoE promoter to gfp revealed that, in vitro, this gene is continuously expressed. Analysis of delta expression in the transposon mutant by quantitative Western blotting revealed a 10-fold reduction in relative abundance (which was linked to the attenuation in virulence that was observed for this mutant) compared to that for the wild-type strain. These data suggest that a minimum intracellular concentration of delta is necessary for this organism to cause disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.