ArticleThe Journal of physiology2006
Vascular adrenergic responsiveness is inversely related to tonic activity of sympathetic vasoconstrictor nerves in humans.
Article in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 139 citations in OpenAlex.
- Risk of methylphenidate-induced prehypertension in normotensive adult smokers with attention deficit hyperactivity disorder.Journal of clinical hypertension (Greenwich, Conn.) · 2013Trial
- Altered neurovascular control of the resting circulation in human metabolic syndrome.The Journal of physiology · 2012Trial
- Age-related differences in the sympathetic-hemodynamic balance in men.Hypertension (Dallas, Tex. : 1979) · 2009Trial
- Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2008Trial
- Autonomic control of blood pressure in women: The roles of hypertension and aging.Autonomic neuroscience : basic & clinical · 2025Review
- Differential effects of female aging on sympathetic blood pressure regulation at rest and during stress in humans.Physiological reports · 2025Article
- Adrenergic control of skeletal muscle blood flow during chronic hypoxia in healthy males.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Flattening the sympathetic-vascular transduction curve.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- The impact of ageing and sex on sympathetic neurocirculatory regulation.Seminars in cell & developmental biology · 2021Review
- The ability of baroreflex activation to improve blood pressure and resistance vessel function in spontaneously hypertensive rats is dependent on stimulation parameters.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Low ventilatory responsiveness to transient hypoxia or breath-holding predicts fast marathon performance in healthy middle-aged and older men.Scientific reports · 2021Article
- Effects of impaired microvascular flow regulation on metabolism-perfusion matching and organ function.Microcirculation (New York, N.Y. : 1994) · 2021Review
- Sex differences in vascular transduction of sympathetic nerve activity.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020Review
- Assessment of resistance vessel function in human skeletal muscle: guidelines for experimental design, Doppler ultrasound, and pharmacology.American journal of physiology. Heart and circulatory physiology · 2020Review
- Relation between resting sympathetic outflow and vasoconstrictor responses to sympathetic nerve bursts: sex differences in healthy young adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Association between beta-adrenoceptor antagonist-induced sympathicolysis and severity of coronary artery disease as assessed by coronary computed tomography angiography (CCTA).The international journal of cardiovascular imaging · 2019Article
- Reliability of pulse waveform separation analysis responses to an orthostatic challenge.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- Interindividual variability in muscle sympathetic responses to static handgrip in young men: evidence for sympathetic responder types?American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Intracranial Pressure Is a Determinant of Sympathetic Activity.Frontiers in physiology · 2018Article
- Resting sympathetic activity is associated with the sympathetically mediated component of energy expenditure following a meal.Physiological reports · 2017Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
In humans, sympathetic nerve activity (SNA) at rest can vary several-fold among normotensive individuals with similar blood pressures. We recently showed that a balance exists between SNA and cardiac output, which may contribute to the maintenance of normal blood pressures over the range of resting SNA levels. In the present studies, we assessed whether variability in vascular adrenergic responsiveness has a role in this balance. We tested the hypothesis that forearm vascular responses to noradrenaline (NA) and tyramine (TYR) are related to SNA such that individuals with lower resting SNA have greater adrenergic responsiveness, and vice-versa. We measured multifibre muscle SNA (MSNA; microneurography), arterial pressure (brachial catheter) and forearm blood flow (plethysmography) in 19 healthy subjects at baseline and during intrabrachial infusions of NA and TYR. Resting MSNA ranged from 6 to 34 bursts min(-1), and was inversely related to vasoconstrictor responsiveness to both NA (r = 0.61, P = 0.01) and TYR (r = 0.52, P = 0.02), such that subjects with lower resting MSNA were more responsive to NA and TYR. We conclude that interindividual variability in vascular adrenergic responsiveness contributes to the balance of factors that maintain normal blood pressure in individuals with differing levels of sympathetic neural activity. Further understanding of this balance may have important implications for our understanding of the pathophysiology of hypertension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.