ArticleJournal of neurology2006
Inflammatory/demyelinating central nervous system involvement in familial Mediterranean fever (FMF): coincidence or association?
Article in Journal of neurology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Neurological involvement in children with familial Mediterranean fever: a systematic review.Pediatric rheumatology online journal · 2025Pooled it
- Identifying high-risk neurological phenotypes in adult-onset classic monogenic autoinflammatory diseases: when should neurologists consider testing?BMC neurology · 2024Pooled it
- Co-occurrence of autoimmune diseases and metabolic disorders in familial mediterranean fever patients: review of literature and case reports.Frontiers in immunology · 2025Review
- Solving a diagnostic dilemma in a patient with periodic fever-When the pieces of the puzzle finally fit.Clinical case reports · 2024Article
- Familial Mediterranean Fever and Transverse Myelitis: A Causal Relation?Neurology and therapy · 2023Article
- An Update on Familial Mediterranean Fever.International journal of molecular sciences · 2023Review
- Neurological and neurodevelopmental symptoms in children with familial Mediterranean fever and their siblings.European journal of pediatrics · 2022Article
- Familial coexistence of demyelinating diseases and familial Mediterranean fever.Rheumatology international · 2022Review
- Positive effects of ocrelizumab in patients with familial mediterranean fever and coexistent multiple sclerosis.Archives of rheumatology · 2021Article
- Neurological phenotypes in patients with NLRP3-, MEFV-, and TNFRSF1A low-penetrance variants.Journal of neuroinflammation · 2020Article
- Familial Mediterranean Fever and Multiple Sclerosis Successfully Treated With Interferon Beta-1a: A Case Report.Archives of rheumatology · 2019Article
- [Neuroimmunology and rheumatology: overlap and differential diagnoses].Der Nervenarzt · 2018Review
- Severity and frequency of restless legs syndrome in patients with familial Mediterranean fever.The Journal of international medical research · 2017Article
- Changes in Cerebral Blood Flow in Patients with Familial Mediterranean Fever.Noro psikiyatri arsivi · 2017Article
- Prevalence and significance of MEFV gene mutations in patients with gouty arthritis.Rheumatology international · 2016Article
- Non-canonical manifestations of familial Mediterranean fever: a changing paradigm.Clinical rheumatology · 2015Review
- Autoinflammatory diseases: a possible cause of thrombosis?Thrombosis journal · 2015Article
- Familial Mediterranean fever and demyelinating plaques in the central nervous system.European journal of rheumatology · 2014Article
- Familial Mediterranean fever: An updated review.European journal of rheumatology · 2014Review
- Association of missense mutations of Mediterranean fever (MEFV) gene with multiple sclerosis in Turkish population.Journal of molecular neuroscience : MN · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveFamilial Mediterranean fever (FMF) is an inherited inflammatory disease characterized by recurrent febrile polyserositis. Central nervous system (CNS) involvement in FMF is uncommon, but recently cases with multiple sclerosis (MS) and FMF have been reported. Here we assess patients with both FMF and MS, in order to clarify any relationship between FMF and MS, and to evaluate disease characteristics. PATIENTS AND
methodsOur MS database between 1986-2005 was screened retrospectively, and patients with both FMF and inflammatory/demyelinating CNS disease were evaluated among a total of 2800 patients including definite MS (n = 2268) and other demyelinating disorders.
resultsThere were 12 patients with FMF, who developed a CNS disorder with multifocal white matter lesions. Median age at onset of FMF was 7 years, and median age at neurological onset was 26.8 years. Nine patients (including two siblings) had definite MS according to clinical and MRI findings, whereas 3 patients had atypical features suggesting other demyelinating disorders. Disease severity varied among the patients between very mild to a fatal course. All 8 patients evaluated for oligoclonal IgG bands in CSF were positive.
conclusionThe rate of FMF among our patients with definite MS is almost 4 times the expected prevalence in Turkey. Our series including a sibling pair concordant for FMF and MS may suggest that similar genetic susceptibility and environmental factors might be responsible, although coincidence still remains a possibility. A prospective study on a larger sample seems to be justified.
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Registered trials
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