ReviewThe Journal of clinical investigation2006
A unique role for Stat5 in recovery from acute anemia.
Review in The Journal of clinical investigation, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- "Do We Know Jack" About JAK? A Closer Look at JAK/STAT Signaling Pathway.Frontiers in oncology · 2018Review
- Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia.Nature medicine · 2013Article
- Article
- Stat5 signaling specifies basal versus stress erythropoietic responses through distinct binary and graded dynamic modalities.PLoS biology · 2012Article
- Peginesatide and erythropoietin stimulate similar erythropoietin receptor-mediated signal transduction and gene induction events.Experimental hematology · 2012Article
- Negative autoregulation by Fas stabilizes adult erythropoiesis and accelerates its stress response.PloS one · 2011Article
- Murine erythroid short-term radioprotection requires a BMP4-dependent, self-renewing population of stress erythroid progenitors.The Journal of clinical investigation · 2010Article
- Article
- Sox6 is necessary for efficient erythropoiesis in adult mice under physiological and anemia-induced stress conditions.PloS one · 2010Article
- Article
- DYRK3 dual-specificity kinase attenuates erythropoiesis during anemia.The Journal of biological chemistry · 2008Article
- Article
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1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The precise role of erythropoietin receptor-activated (EpoR-activated) Stat5 in the regulation of erythropoiesis remains unclear. In this issue of the JCI, Menon and colleagues present new experimental data that indicate a distinct role for Stat5 in the regulation of stress-induced erythropoiesis, such as during acute anemic states (see the related article beginning on page 683). A critical function for Stat5 is to promote cell survival, possibly through transcriptional induction of the antiapoptotic protein Bcl-x. In the present experimental system, erythropoietin-Stat5 signals did not induce Bcl-x expression but did induce oncostatin-M. Moreover, oncostatin-M was found to enhance survival of erythroid progenitors. This work differentiates between steady-state (or homeostatic) erythropoiesis and stress-induced erythropoiesis at the level of EpoR signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.