ArticleGenes and immunity2006
Interleukin-20 promotes angiogenesis in a direct and indirect manner.
Article in Genes and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 109 citations in OpenAlex.
- Expression of IL-20 in synovium and lesional skin of patients with psoriatic arthritis: differential response to alefacept treatment.Arthritis research & therapy · 2012Trial
- Targeting vascular endothelial growth factor (VEGF)-induced angiogenesis withNutrition research and practice · 2026Article
- Applications of Matrix Metalloproteinase-9-Related Nanomedicines in Tumors and Vascular Diseases.Pharmaceutics · 2025Review
- The Role of Microvascular Variations in the Process of Intervertebral Disk Degeneration and Its Regulatory Mechanisms: A Literature Review.Orthopaedic surgery · 2024Review
- Spatial immunophenotypes predict clinical outcome in intrahepatic cholangiocarcinoma.JHEP reports : innovation in hepatology · 2023Article
- Dual Role of Interleukin-20 in Different Stages of Osteoclast Differentiation and Its Osteoimmune Regulation during Alveolar Bone Remodeling.International journal of molecular sciences · 2023Article
- IL-20 is involved in obesity by modulation of adipogenesis and macrophage dysregulation.Immunology · 2021Article
- Expression of IL-20 Receptor Subunit β Is Linked to EAE Neuropathology and CNS Neuroinflammation.Frontiers in cellular neuroscience · 2021Article
- IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models.Nature communications · 2020Article
- Anti-IL-20 antibody improved motor function and reduced glial scar formation after traumatic spinal cord injury in rats.Journal of neuroinflammation · 2020Article
- IL-20 in Acute Kidney Injury: Role in Pathogenesis and Potential as a Therapeutic Target.International journal of molecular sciences · 2020Review
- Effects of IL-1β, IL-20, and BMP-2 on Intervertebral Disc Inflammation under Hypoxia.Journal of clinical medicine · 2020Article
- Psammomys obesus: a Natural Diet-Controlled Model for Diabetes and Cardiovascular Diseases.Current atherosclerosis reports · 2018Review
- IL-20 bone diseases involvement and therapeutic target potential.Journal of biomedical science · 2018Review
- The roles of IL-19 and IL-20 in the inflammation of degenerative lumbar spondylolisthesis.Journal of inflammation (London, England) · 2018Article
- IL-19 and Other IL-20 Family Member Cytokines in Vascular Inflammatory Diseases.Frontiers in immunology · 2018Review
- Anti-IL-20 monoclonal antibody inhibited tumor growth in hepatocellular carcinoma.Scientific reports · 2017Article
- Interleukin-20 targets podocytes and is upregulated in experimental murine diabetic nephropathy.Experimental & molecular medicine · 2017Article
- Interleukin-19 induces angiogenesis in the absence of hypoxia by direct and indirect immune mechanisms.American journal of physiology. Cell physiology · 2016Article
- Macrophages: An Inflammatory Link Between Angiogenesis and Lymphangiogenesis.Microcirculation (New York, N.Y. : 1994) · 2016Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
IL-20 belongs to the IL-10 family and is involved in the pathogenesis of keratinocyte hyperproliferation in vivo. Endothelial cells express IL-20 receptors. To explore the function of IL-20 on endothelial cells, we treated human umbilical vein endothelial cells (HUVECs) and human microvascular endothelial cells (HMECs) with human IL-20 and analyzed its effect on endothelial cells. IL-20 induced proliferation of endothelial cells and the activity was specifically blocked by anti-human-IL-20 monoclonal antibody and soluble (s)IL-20 receptor (R)1 and sIL-20R2. An alternatively spliced variant of IL-20 was isolated and also was shown to induce proliferation of HUVECs and HMECs. Treatment of HUVECs with both IL-10 and IL-20 demonstrated that IL-10 antagonized the activity of IL-20 because it diminished IL-20-induced proliferation of HUVECs. IL-20 significantly induced HUVECs migration and vascular tube formation on Matrigel in vitro. In vivo, IL-20 also enhanced tumor angiogenesis. Incubation of IL-20 with HUVECs induced transcripts of bFGF, VEGF, MMP-2, MMP-9, and IL-8. Furthermore, incubation of HUVECs with IL-20 induced phosphorylation of ERK1/2, p38, and JNK. Thus, IL-20 is a pleiotropic cytokine and promotes angiogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.