ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2006
Long-term effects of analgesics in a population of elderly nursing home residents with persistent nonmalignant pain.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Predictors and Clinical Outcomes of Long-Term Opioid Therapy in Older Adults: A Systematic Review.Pharmacotherapy · 2026Pooled it
- The burden of respiratory infections among older adults in long-term care: a systematic review.BMC geriatrics · 2019Pooled it
- The prevalence, impact and management of musculoskeletal disorders in older people living in care homes: a systematic review.Rheumatology international · 2016Pooled it
- Comparison of the Impacts of Under-Treated Pain and Opioid Pain Medication on Cognitive Impairment.Cureus · 2022Review
- Long-Term Pain Characteristics and Management Following Minimally Invasive Spinal Decompression and Open Laminectomy and Fusion for Spinal Stenosis.Medicina (Kaunas, Lithuania) · 2021Article
- Multiple imputation to quantify misclassification in observational studies of the cognitively impaired: an application for pain assessment in nursing home residents.BMC medical research methodology · 2021Article
- Social Connection in Long-Term Care Homes: A Scoping Review of Published Research on the Mental Health Impacts and Potential Strategies During COVID-19.Journal of the American Medical Directors Association · 2021Article
- Opioid Prescribing in the Elderly: A Systematic Review.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2020Review
- Chronic Pain Management in the Elderly.Anesthesiology clinics · 2019Review
- Clinical characteristics associated with the onset of delirium among long-term nursing home residents.BMC geriatrics · 2018Article
- Prevalence of Long-Term Opioid Use in Long-Stay Nursing Home Residents.Journal of the American Geriatrics Society · 2018Article
- Social Engagement After Nursing Home Admission: Racial and Ethnic Disparities and Risk Factors.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2017Observational
- Article
- Guidance on opioids prescribing for the management of persistent non-cancer pain in older adults.World journal of clinical cases · 2017Review
- Nursing staff induced repositionings and immobile patients' spontaneous movements in nursing care.International wound journal · 2016Article
- [Analgesics in geriatric patients. Adverse side effects and interactions].Zeitschrift fur Gerontologie und Geriatrie · 2015Article
- Rehabilitation after hip fracture.Wiener medizinische Wochenschrift (1946) · 2013Review
- The relationship between pain and disruptive behaviors in nursing home residents with dementia.BMC geriatrics · 2013Article
- Medical and psychological risks and consequences of long-term opioid therapy in women.Pain medicine (Malden, Mass.) · 2012Review
- Effects of morphine on thermal sensitivity in adult and aged rats.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundLittle is known about the long-term effects of analgesics on functional status and well-being of nursing home residents with chronic pain.
methodsUsing the Minimum Data Set, we performed a longitudinal study of nursing home residents (n = 10,372) with persistent pain. Using propensity score adjustment techniques, we compared the effect of different analgesics on changes in physical, cognitive, emotional, and social functioning, and examined rates of adverse events over a 6-month period.
resultsThere was no change in the analgesic class for at least 6 months for 35.4% of residents, including 40% who received no analgesics during this time. Use of nonopioids was 37.9%, short-acting opioids was 18.9%, and long-acting opioids was 3.3%. We found improvement in functional status (adjusted hazard ratio = 1.85; 95% confidence interval [CI], 1.05-3.23) and social engagement (adjusted hazard ratio = 1.58; 95%, CI, 0.99-2.50) with long-acting opioids compared with short-acting opioids. There were no changes in cognitive status or mood status, or increased risk of depression with use of any analgesics, including opioids. There was a trend toward a lower risk of falls with use of any analgesics (adjusted odds ratio = 0.87; 95% CI, 0.70-1.06). Rates of other adverse events (i.e., constipation, delirium, dehydration, pneumonia) were not found to be higher among chronic opioid users compared to those taking no analgesics or nonopioids.
conclusionsThe use of long-acting opioids may be a relatively safe option in the management of persistent nonmalignant pain in the nursing home population, yielding benefits in functional status and social engagement.
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Registered trials
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