Evidence map›Paper›PMID 16510789›Full record

ArticleGenetics2006

Association mapping with single-feature polymorphisms.

Sung Kim, Keyan Zhao, Rong Jiang, John Molitor, Justin O Borevitz, Magnus Nordborg, Paul Marjoram

Abstract read
In one paragraph

Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Combining bulk segregation analysis and microarrays for mapping of the pH trait in melon.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2013
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  11. Genome-wide patterns of single-feature polymorphism in Arabidopsis thaliana.Proceedings of the National Academy of Sciences of the United States of America · 2007
    Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sung KimDepartment of Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089-2910, USA.
Keyan Zhao
Rong Jiang
John Molitor
Justin O Borevitz
Magnus Nordborg
Paul Marjoram

Funding

Implications of haplotype structure in the human genomeP50HG002790 · NHGRI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TAVARE, SIMON · 2003 to 2013
$29.9M
Computational Methods for Fine MappingR01GM069890 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MARJORAM, PAUL · 2004 to 2007
$1.9M
NHGRI NIH HHS HG002790-01A1NHGRI NIH HHS P50 HG002790NIGMS NIH HHS R01 GM069890PHS HHS FM069890-01A1
6 · The paper itself

Abstract

We develop methods for exploiting "single-feature polymorphism" data, generated by hybridizing genomic DNA to oligonucleotide expression arrays. Our methods enable the use of such data, which can be regarded as very high density, but imperfect, polymorphism data, for genomewide association or linkage disequilibrium mapping. We use a simulation-based power study to conclude that our methods should have good power for organisms like Arabidopsis thaliana, in which linkage disequilibrium is extensive, the reason being that the noisiness of single-feature polymorphism data is more than compensated for by their great number. Finally, we show how power depends on the accuracy with which single-feature polymorphisms are called.

Indexed as

Polymorphism, GeneticAlgorithmsAllelesArabidopsisChromosome MappingCluster AnalysisData Interpretation, StatisticalGenetic MarkersHaplotypesLinkage DisequilibriumModels, GeneticGenetic Markers

Identifiers

PMID16510789
PMCPMC1526505

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.