ArticleGenetics2006
Quantitative trait loci controlling refractoriness to Plasmodium falciparum in natural Anopheles gambiae mosquitoes from a malaria-endemic region in western Kenya.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Evolution of resistance and disease tolerance mechanisms to oral bacterial infection inOpen biology · 2025Article
- Genome-wide association studies of severe P. falciparum malaria susceptibility: progress, pitfalls and prospects.BMC medical genomics · 2019Review
- Proteome-wide analysis of Anopheles culicifacies mosquito midgut: new insights into the mechanism of refractoriness.BMC genomics · 2018Article
- Association mapping by pooled sequencing identifies TOLL 11 as a protective factor against Plasmodium falciparum in Anopheles gambiae.BMC genomics · 2015Article
- The kdr-bearing haplotype and susceptibility to Plasmodium falciparum in Anopheles gambiae: genetic correlation and functional testing.Malaria journal · 2015Article
- Constructing a Genome-Wide LD Map of Wild A. gambiae Using Next-Generation Sequencing.BioMed research international · 2015Article
- The Anopheles innate immune system in the defense against malaria infection.Journal of innate immunity · 2014Review
- Genome-block expression-assisted association studies discover malaria resistance genes in Anopheles gambiae.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Fine-scale analysis of parasite resistance genes in the red flour beetle, Tribolium castaneum.Genetics · 2013Article
- Evidence for population-specific positive selection on immune genes of Anopheles gambiae.G3 (Bethesda, Md.) · 2012Article
- Anopheles gambiae pathogen susceptibility: the intersection of genetics, immunity and ecology.Current opinion in microbiology · 2012Review
- Article
- Exceptional diversity, maintenance of polymorphism, and recent directional selection on the APL1 malaria resistance genes of Anopheles gambiae.PLoS biology · 2011Article
- Article
- Transmission and cross-mating of high-level resistance Plasmodium falciparum dihydrofolate reductase haplotypes in The Gambia.The American journal of tropical medicine and hygiene · 2010Article
- Fine pathogen discrimination within the APL1 gene family protects Anopheles gambiae against human and rodent malaria species.PLoS pathogens · 2009Article
- Article
- Introduction. Ecological immunology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Article
- Conserved mosquito/parasite interactions affect development of Plasmodium falciparum in Africa.PLoS pathogens · 2008Article
- A major genetic locus controlling natural Plasmodium falciparum infection is shared by East and West African Anopheles gambiae.Malaria journal · 2007Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Natural anopheline populations exhibit much variation in ability to support malaria parasite development, but the genetic mechanisms underlying this variation are not clear. Previous studies in Mali, West Africa, identified two quantitative trait loci (QTL) in Anopheles gambiae mosquitoes that confer refractoriness (failure of oocyst development in mosquito midguts) to natural Plasmodium falciparum parasites. We hypothesize that new QTL may be involved in mosquito refractoriness to malaria parasites and that the frequency of natural refractoriness genotypes may be higher in the basin region of Lake Victoria, East Africa, where malaria transmission intensity and parasite genetic diversity are among the highest in the world. Using field-derived F2 isofemale families and microsatellite marker genotyping, two loci significantly affecting oocyst density were identified: one on chromosome 2 between markers AG2H135 and AG2H603 and the second on chromosome 3 near marker AG3H93. The first locus was detected in three of the five isofemale families studied and colocalized to the same region as Pen3 and pfin1 described in other studies. The second locus was detected in two of the five isofemale families, and it appears to be a new QTL. QTL on chromosome 2 showed significant additive effects while those on chromosome 3 exhibited significant dominant effects. Identification of P. falciparum-refractoriness QTL in natural An. gambiae mosquitoes is critical to the identification of the genes involved in malaria parasite transmission in nature and for understanding the coevolution between malaria parasites and mosquito vectors.
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