ArticleGenetics2006
Synthetic gene recruitment reveals adaptive reprogramming of gene regulation in yeast.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- A Model of Epigenetic Inheritance Accounts for Unexpected Adaptation to Unforeseen Challenges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Basal Xenobot transcriptomics reveals changes and novel control modality in cells freed from organismal influence.Communications biology · 2025Article
- Cancer progression as a learning process.iScience · 2022Review
- Metabolic cost of rapid adaptation of single yeast cells.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Computational modeling demonstrates that glioblastoma cells can survive spatial environmental challenges through exploratory adaptation.Nature communications · 2019Article
- Article
- Exploratory adaptation in large random networks.Nature communications · 2017Article
- Cell signaling as a cognitive process.The EMBO journal · 2017Review
- A principle of organization which facilitates broad Lamarckian-like adaptations by improvisation.Biology direct · 2015Article
- Global coordination in adaptation to gene rewiring.Nucleic acids research · 2015Article
- The genome as a developmental organ.The Journal of physiology · 2014Review
- Article
- Article
- Population dynamics of metastable growth-rate phenotypes.PloS one · 2013Article
- Robustness of a rhythmic circuit to short- and long-term temperature changes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Article
- Adaptation by stochastic switching of a monostable genetic circuit in Escherichia coli.Molecular systems biology · 2011Article
- Article
- Bacterial cells carrying synthetic dual-function operon survived starvation.Journal of biomedicine & biotechnology · 2011Article
- Collective dynamics of gene expression in cell populations.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The recruitment of a gene to a foreign regulatory system is a major evolutionary event that can lead to novel phenotypes. However, the evolvability potential of cells depends on their ability to cope with challenges presented by gene recruitment. To study this ability, we combined synthetic gene recruitment with continuous culture and online measurements of the metabolic and regulatory dynamics over long timescales. The gene HIS3 from the histidine synthesis pathway was recruited to the GAL system, responsible for galactose utilization in the yeast S. cerevisiae. Following a switch from galactose to glucose--from induced to repressed conditions of the GAL system--in histidine-lacking chemostats (where the recruited HIS3 is essential), the regulatory system reprogrammed to adaptively tune HIS3 expression, allowing the cells to grow competitively in pure glucose. The adapted state was maintained for hundreds of generations in various environments. The timescales involved and the reproducibility of separate experiments render spontaneous mutations an unlikely underlying mechanism. Essentially all cells could adapt, excluding selection over a genetically variable population. The results reveal heritable adaptation induced by the exposure to glucose. They demonstrate that genetic regulatory networks have the potential to support highly demanding events of gene recruitment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.