ArticleVirology2006
Mouse hepatitis virus pathogenesis in the central nervous system is independent of IL-15 and natural killer cells.
Article in Virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
- Advances in viral encephalitis: Viral transmission, host immunity, and experimental animal models.Zoological research · 2023Review
- Neuronal Ablation of Alpha/Beta Interferon (IFN-α/β) Signaling Exacerbates Central Nervous System Viral Dissemination and Impairs IFN-γ Responsiveness in Microglia/Macrophages.Journal of virology · 2020Article
- Myd88 Initiates Early Innate Immune Responses and Promotes CD4 T Cells during Coronavirus Encephalomyelitis.Journal of virology · 2015Article
- Immune responses to non-tumor antigens in the central nervous system.Frontiers in oncology · 2014Review
- Review
- CXCR2 signaling and host defense following coronavirus-induced encephalomyelitis.Future virology · 2012Article
- Shifting hierarchies of interleukin-10-producing T cell populations in the central nervous system during acute and persistent viral encephalomyelitis.Journal of virology · 2011Article
- CXCR3-dependent plasma blast migration to the central nervous system during viral encephalomyelitis.Journal of virology · 2011Article
- Factors supporting intrathecal humoral responses following viral encephalomyelitis.Journal of virology · 2011Article
- Gamma interferon signaling in oligodendrocytes is critical for protection from neurotropic coronavirus infection.Journal of virology · 2010Article
- The pathogenesis of murine coronavirus infection of the central nervous system.Critical reviews in immunology · 2010Review
- Interleukin-12 (IL-12), but not IL-23, deficiency ameliorates viral encephalitis without affecting viral control.Journal of virology · 2009Article
- The Biology of Persistent Infection: Inflammation and Demyelination following Murine Coronavirus Infection of the Central Nervous System.Current immunology reviews · 2009Article
- Target-dependent B7-H1 regulation contributes to clearance of central nervous system infection and dampens morbidity.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- IL-15 independent maintenance of virus-specific CD8(+) T cells in the CNS during chronic infection.Journal of neuroimmunology · 2009Article
- Memory CD4+ T-cell-mediated protection from lethal coronavirus encephalomyelitis.Journal of virology · 2008Article
- Mouse hepatitis virus infection of the CNS: a model for defense, disease, and repair.Frontiers in bioscience : a journal and virtual library · 2008Article
- NKG2D receptor signaling enhances cytolytic activity by virus-specific CD8+ T cells: evidence for a protective role in virus-induced encephalitis.Journal of virology · 2008Article
- CD4 T cells contribute to virus control and pathology following central nervous system infection with neurotropic mouse hepatitis virus.Journal of virology · 2008Article
- Type I interferons are essential in controlling neurotropic coronavirus infection irrespective of functional CD8 T cells.Journal of virology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Infection by the neurotropic JHM strain of mouse hepatitis virus (JHMV) results in an acute encephalomyelitis associated with demyelination. T cells are critical in controlling viral replication, but also contribute to central nervous system (CNS) pathogenesis. To reveal a role for innate effectors in anti-viral immunity and neurological disease, JHMV pathogenesis was studied in mice deficient in interleukin-15 (IL-15-/-) and natural killer (NK) cells. Clinical disease, CNS inflammation and demyelination in infected IL-15-/- mice were similar to wild-type mice. Despite the absence of NK cells and suboptimal CD8+ T cell responses, IL-15-/- mice controlled JHMV replication as efficiently as wild-type mice. Similar kinetics of class I and class II upregulation on microglia further suggested no role of NK cells in regulating major histocompatibility complex (MHC) molecule expression on resident CNS cells. IL-15 and NK cells thus appear dispensable for anti-viral immunity and CNS pathogenesis during acute JHMV infection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.