ArticleMolecular and cellular biology2006
Condensin loaded onto the replication fork barrier site in the rRNA gene repeats during S phase in a FOB1-dependent fashion to prevent contraction of a long repetitive array in Saccharomyces cerevisiae.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 52 citations in OpenAlex.
- Spatial Organization of Chromatin: Emergence of Chromatin Structure During Development.Annual review of cell and developmental biology · 2021Review
- Systematic profiling of protein complex dynamics reveals DNA-PK phosphorylation of IFI16 en route to herpesvirus immunity.Science advances · 2021Article
- Knockdown of Dinoflagellate CondensinMicroorganisms · 2020Article
- Review
- Phenotypic and Genotypic Consequences of CRISPR/Cas9 Editing of the Replication Origins in the rDNA ofGenetics · 2019Article
- Transient crosslinking kinetics optimize gene cluster interactions.PLoS computational biology · 2019Article
- Condensin action and compaction.Current genetics · 2019Review
- Condensin Depletion Causes Genome Decompaction Without Altering the Level of Global Gene Expression inGenetics · 2018Article
- Condensin ATPase motifs contribute differentially to the maintenance of chromosome morphology and genome stability.PLoS biology · 2018Article
- Condensins promote chromosome individualization and segregation during mitosis, meiosis, and amitosis inMolecular biology of the cell · 2018Article
- Impaired cohesion and homologous recombination during replicative aging in budding yeast.Science advances · 2018Article
- Enrichment of dynamic chromosomal crosslinks drive phase separation of the nucleolus.Nucleic acids research · 2017Article
- The loading of condensin in the context of chromatin.Current genetics · 2017Review
- Article
- Levels of Ycg1 Limit Condensin Function during the Cell Cycle.PLoS genetics · 2016Article
- Condensin and Hmo1 Mediate a Starvation-Induced Transcriptional Position Effect within the Ribosomal DNA Array.Cell reports · 2016Article
- Condensins and 3D Organization of the Interphase Nucleus.Current genetic medicine reports · 2013Article
- Condensin: crafting the chromosome landscape.Chromosoma · 2013Review
- Condensins: universal organizers of chromosomes with diverse functions.Genes & development · 2012Review
- "Chromosome kissing" and modulation of replication termination.Bioarchitecture · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An average of 200 copies of the rRNA gene (rDNA) is clustered in a long tandem array in Saccharomyces cerevisiae. FOB1 is known to be required for expansion/contraction of the repeats by stimulating recombination, thereby contributing to the maintenance of the average copy number. In Deltafob1 cells, the repeats are still maintained without any fluctuation in the copy number, suggesting that another, unknown system acts to prevent repeat contraction. Here, we show that condensin acts together with FOB1 in a functionally complemented fashion to maintain the long tandem repeats. Six condensin mutants possessing severely contracted rDNA repeats were isolated in Deltafob1 cells but not in FOB1+ cells. We also found that the condensin complex associated with the nontranscribed spacer region of rDNA with a major peak coincided with the replication fork barrier (RFB) site in a FOB1-dependent fashion. Surprisingly, condensin association with the RFB site was established during S phase and was maintained until anaphase. These results indicate that FOB1 plays a novel role in preventing repeat contraction by regulating condensin association and suggest a link between replication termination and chromosome condensation and segregation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.