ArticleMolecular and cellular biology2006
Differential methylation of Xite and CTCF sites in Tsix mirrors the pattern of X-inactivation choice in mice.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 55 citations in OpenAlex.
- Multifaceted role of CTCF in X-chromosome inactivation.Chromosoma · 2024Review
- When Oxidative Stress Meets Epigenetics: Implications in Cancer Development.Antioxidants (Basel, Switzerland) · 2020Review
- Genetic Intersection of Tsix and Hedgehog Signaling during the Initiation of X-Chromosome Inactivation.Developmental cell · 2017Article
- Potential Role of Methylation Marker in Glioma Supporting Clinical Decisions.International journal of molecular sciences · 2016Article
- A prominent and conserved role for YY1 in Xist transcriptional activation.Nature communications · 2014Article
- Loss of DNMT1o disrupts imprinted X chromosome inactivation and accentuates placental defects in females.PLoS genetics · 2013Article
- Gene expression and DNA methylation status of chicken primordial germ cells.Molecular biotechnology · 2013Article
- Epigenetics: judge, jury and executioner of stem cell fate.Epigenetics · 2012Review
- YY1 associates with the macrosatellite DXZ4 on the inactive X chromosome and binds with CTCF to a hypomethylated form in some male carcinomas.Nucleic acids research · 2012Article
- A repetitive elements perspective in Polycomb epigenetics.Frontiers in genetics · 2012Article
- Regulation of X-chromosome inactivation by the X-inactivation centre.Nature reviews. Genetics · 2011Review
- Variability of sequence surrounding the Xist gene in rodents suggests taxon-specific regulation of X chromosome inactivation.PloS one · 2011Article
- X chromosome inactivation and autoimmunity.Clinical reviews in allergy & immunology · 2010Review
- A survey of well conserved families of C2H2 zinc-finger genes in Daphnia.BMC genomics · 2010Article
- Article
- A role for non-coding Tsix transcription in partitioning chromatin domains within the mouse X-inactivation centre.Epigenetics & chromatin · 2009Article
- CTCF: master weaver of the genome.Cell · 2009Review
- Genomic imprinting mechanisms in mammals.Mutation research · 2008Review
- DXZ4 chromatin adopts an opposing conformation to that of the surrounding chromosome and acquires a novel inactive X-specific role involving CTCF and antisense transcripts.Genome research · 2008Article
- Higher order chromatin structure at the X-inactivation center via looping DNA.Developmental biology · 2008Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
During mammalian dosage compensation, one of two X-chromosomes in female cells is inactivated. The choice of which X is silenced can be imprinted or stochastic. Although genetic loci influencing the choice decision have been identified, the primary marks for imprinting and random selection remain undefined. Here, we examined the role of DNA methylation, a mechanism known to regulate imprinting in autosomal loci, and sought to determine whether differential methylation on the two Xs might predict their fates. To identify differentially methylated domains (DMDs) at the X-inactivation center, we used bisulfite sequencing and methylation-sensitive restriction enzyme analyses. We found DMDs in Tsix and Xite, two genes previously shown to influence choice. Interestingly, the DMDs in Tsix lie within CTCF binding sites. Allelic methylation differences occur in gametes and are erased in embryonic stem cells carrying two active Xs. Because the pattern of DNA methylation mirrors events of X-inactivation, we propose that differential methylation of DMDs in Tsix and Xite constitute a primary mark for epigenetic regulation. The discovery of DMDs in CTCF sites draws further parallels between X-inactivation and autosomal imprinting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.