ArticleEnvironmental health perspectives2006
Instillation of six different ultrafine carbon particles indicates a surface area threshold dose for acute lung inflammation in mice.
Article in Environmental health perspectives, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
107 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Research recommendations for selected IARC-classified agents.Environmental health perspectives · 2010Pooled it
- Pulmonary toxicity of brake wear particles: effects of composition and surface reactivity.Particle and fibre toxicology · 2026Article
- Intratracheal instillation for the testing of pulmonary toxicity in mice-Effects of instillation devices and feed type on inflammation.Animal models and experimental medicine · 2025Article
- Challenges in Observation of Ultrafine Particles: Addressing Estimation Miscalculations and the Necessity of Temporal Trends.Environmental science & technology · 2025Article
- Spatiotemporal Mapping of Ultrafine Particle Fluxes in an Office HVAC System with a Diffusion Charger Sensor Array.ACS ES&T air · 2025Article
- Oxide-Perovskites for Automotive Catalysts Biotransform and Induce Multicomponent Clearance and Hazard.ACS nano · 2024Article
- Correlation between Exposure to UFP and ACE/ACE2 Pathway: Looking for Possible Involvement in COVID-19 Pandemic.Toxics · 2024Article
- Air pollution and survival in patients with malignant mesothelioma and asbestos-related lung cancer: a follow-up study of 1591 patients in South Korea.Environmental health : a global access science source · 2024Article
- Article
- Correlation gas chromatography and two-dimensional volatility basis methods to predict gas-particle partitioning for e-cigarette aerosols.Aerosol science and technology : the journal of the American Association for Aerosol Research · 2024Article
- Adjuvant effect of inhaled particulate matter containing free radicals following house-dust mite induction of asthma in mice.Inhalation toxicology · 2023Article
- The impact of coal mine dust characteristics on pathways to respiratory harm: investigating the pneumoconiotic potency of coals.Environmental geochemistry and health · 2023Review
- Multi-instrument assessment of fine and ultrafine titanium dioxide aerosols.Journal of toxicology and environmental health. Part A · 2023Article
- Influence of Impurities from Manufacturing Process on the Toxicity Profile of Boron Nitride Nanotubes.Small (Weinheim an der Bergstrasse, Germany) · 2022Article
- High-efficiency mechanically assisted alkaline extraction of nanoparticles from biological tissues for spICP-MS analysis.Analytical and bioanalytical chemistry · 2022Article
- Gestational exposure to titanium dioxide, diesel exhaust, and concentrated urban air particles affects levels of specialized pro-resolving mediators in response to allergen in asthma-susceptible neonate lungs.Journal of toxicology and environmental health. Part A · 2022Article
- Comparison of biological responses between submerged, pseudo-air-liquid interface, and air-liquid interface exposure of A549 and differentiated THP-1 co-cultures to combustion-derived particles.Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering · 2022Article
- Development and application of a health-based framework for informing regulatory action in relation to exposure of microplastic particles in California drinking water.Microplastics and nanoplastics · 2022Article
- Influence of fine particulate matter and its pure particulate fractions on pulmonary immune cells and cytokines in mice.Experimental and therapeutic medicine · 2021Article
- Chronic exposure to diesel exhaust may cause small airway wall thickening without lumen narrowing: a quantitative computerized tomography study in Chinese diesel engine testers.Particle and fibre toxicology · 2021Article
47 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Increased levels of particulate air pollution are associated with increased respiratory and cardiovascular mortality and morbidity. Some epidemiologic and toxicologic research suggests ultrafine particles (UFPs) (< 100 nm) to be more harmful per unit mass than larger particles. Our study was aimed at a quantitative comparison of acute adverse effects of different types of carbonaceous UFPs at a dose range that causes a moderate inflammatory response in lungs. We used six different particle types (primary particle size 10-50 nm, specific surface area 30-800 m2/g, and organic content 1-20%): PrintexG, Printex90, flame soot particles with different organic content (SootL, SootH), spark-generated ultrafine carbon particles (ufCP), and the reference diesel exhaust particles (DEP) SRM1650a. Mice were instilled with 5, 20, and 50 microg of each particle type, and bronchoalveolar lavage was analyzed 24 hr after instillation for inflammatory cells and the level of proinflammatory cytokines. At respective mass-doses, particle-caused detrimental effects ranked in the following order: ufCP > SootL > or = SootH > Printex90 > PrintexG > DEP. Relating the inflammatory effects to the particle characteristics--organic content, primary particle size, or specific surface area--demonstrates the most obvious dose response for particle surface area. Our study suggests that the surface area measurement developed by Brunauer, Emmett, and Teller is a valuable reference unit for the assessment of causative health effects for carbonaceous UFPs. Additionally, we demonstrated the existence of a threshold for the particle surface area at an instilled dose of approximately 20 cm2, below which no acute proinflammatory responses could be detected in mice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.