ArticleCritical care (London, England)2006
Lung and 'end organ' injury due to mechanical ventilation in animals: comparison between the prone and supine positions.
Article in Critical care (London, England), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 51 citations in OpenAlex.
- Pulmonary and Extrapulmonary Effects of Prolonged Prone Positioning in a Porcine Model of Acute Respiratory Distress Syndrome.Shock (Augusta, Ga.) · 2025Article
- Exogenous surfactant reduces inflammation and redox imbalance in rats under prone or supine mechanical ventilation.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Future directions in ventilator-induced lung injury associated cognitive impairment: a new sight.Frontiers in physiology · 2023Review
- Review
- Article
- Deterioration of Regional Lung Strain and Inflammation during Early Lung Injury.American journal of respiratory and critical care medicine · 2018Article
- Treatment of ARDS With Prone Positioning.Chest · 2017Review
- Efficacy of prone position in acute respiratory distress syndrome patients: A pathophysiology-based review.World journal of critical care medicine · 2016Review
- Prone position ameliorates lung elastance and increases functional residual capacity independently from lung recruitment.Intensive care medicine experimental · 2015Article
- New and conventional strategies for lung recruitment in acute respiratory distress syndrome.Critical care (London, England) · 2010Review
- Effects of frequency and inspiratory plateau pressure during recruitment manoeuvres on lung and distal organs in acute lung injury.Intensive care medicine · 2009Article
- Relationship between gas exchange response to prone position and lung recruitability during acute respiratory failure.Intensive care medicine · 2009Article
- Effects of overinflation on procollagen type III expression in experimental acute lung injury.Critical care (London, England) · 2007Article
- Year in review 2006: Critical Care--Respirology.Critical care (London, England) · 2007Review
- Reducing ventilator-induced lung injury and other organ injury by the prone position.Critical care (London, England) · 2006Review
Corrections and comments
- Commented on by
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionUse of the prone position in patients with acute lung injury improves their oxygenation. Most of these patients die from multisystem organ failure and not from hypoxia, however. Moreover, there is some evidence that the organ failure is caused by increased cell apoptosis. In the present study we therefore examined whether the position of the patients affects histological changes and apoptosis in the lung and 'end organs', including the brain, heart, diaphragm, liver, kidneys and small intestine.
methodsTen mechanically ventilated sheep with a tidal volume of 15 ml/kg body weight were studied for 90 minutes. Five sheep were placed in the supine position and five sheep were placed in the prone position during the experiment. Lung changes were analyzed histologically using a semiquantitative scoring system and the extent of apoptosis was investigated with the TUNEL method.
resultsIn the supine position intra-alveolar hemorrhage appeared predominantly in the dorsal areas, while the other histopathologic lesions were homogeneously distributed throughout the lungs. In the prone position, all histological changes were homogeneously distributed. A significantly higher score of lung injury was found in the supine position than in the prone position (4.63 +/- 0.58 and 2.17 +/- 0.19, respectively) (P < 0.0001). The histopathologic changes were accompanied by increased apoptosis (TUNEL method). In the supine position, the apoptotic index in the lung and in most of the 'end organs' was significantly higher compared with the prone position (all P < 0.005). Interestingly, the apoptotic index was higher in dorsal areas compared with ventral areas in both the prone and supine positions (P < 0.003 and P < 0.02, respectively).
conclusionOur results suggest that the prone position appears to reduce the severity and the extent of lung injury, and is associated with decreased apoptosis in the lung and 'end organs'.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.