ArticleCritical care (London, England)2006
CC and CXC chemokine levels in children with meningococcal sepsis accurately predict mortality and disease severity.
Article in Critical care (London, England), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Plasma interleukin-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shock.Critical care medicine · 2010Trial
- CXCL10 rs8878 identifies a genotype-associated immune phenotype linked to T-lymphocyte preservation and survival in sepsis.Frontiers in immunology · 2026Article
- Refining empiric subgroups of pediatric sepsis using machine-learning techniques on observational data.Frontiers in pediatrics · 2023Review
- The Actin-Binding Protein Cortactin Promotes Sepsis Severity by Supporting Excessive Neutrophil Infiltration into the Lung.Biomedicines · 2022Article
- Monocyte Chemoattractant Protein-1, a Possible Biomarker of Multiorgan Failure and Mortality in Ventilator-Associated Pneumonia.International journal of molecular sciences · 2019Article
- Diagnosis and Prognosis of Sepsis Based on Use of Cytokines, Chemokines, and Growth Factors.Disease markers · 2019Article
- Differences in IgG Fc Glycosylation Are Associated with Outcome of Pediatric Meningococcal Sepsis.mBio · 2018Article
- Selected Biomarkers Correlate with the Origin and Severity of Sepsis.Mediators of inflammation · 2018Article
- Acetylsalicylic acid differentially limits the activation and expression of cell death markers in human platelets exposed to Staphylococcus aureus strains.Scientific reports · 2017Article
- Inflammatory Kidney and Liver Tissue Response to Different Hydroxyethylstarch (HES) Preparations in a Rat Model of Early Sepsis.PloS one · 2016Article
- Insight into the beneficial immunomodulatory mechanism of the sevoflurane metabolite hexafluoro-2-propanol in a rat model of endotoxaemia.Clinical and experimental immunology · 2015Article
- Article
- Sepsis biomarkers: a review.Critical care (London, England) · 2010Review
- Interleukin-8 as a stratification tool for interventional trials involving pediatric septic shock.American journal of respiratory and critical care medicine · 2008Article
- Elevated serum levels of IL-1ra in children with Plasmodium falciparum malaria are associated with increased severity of disease.Cytokine · 2008Article
- Sepsis mediators.Current infectious disease reports · 2007Article
- Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis.Critical care (London, England) · 2007Article
- Year in review 2006: Critical Care--Paediatrics.Critical care (London, England) · 2007Review
- Meningococcal disease: identifying high-risk cases.Critical care (London, England) · 2006Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionChemokines are a superfamily of small peptides involved in leukocyte chemotaxis and in the induction of cytokines in a wide range of infectious diseases. Little is known about their role in meningococcal sepsis in children and their relationship with disease severity and outcome.
methodsMonocyte chemoattractant protein (MCP)-1, macrophage inflammatory protein (MIP) 1alpha, growth-related gene product (GRO)-alpha and interleukin (IL)-8 were measured in 58 children with meningococcal sepsis or septic shock on admission and 24 hours thereafter. Nine patients died. Serum chemokine levels of survivors and nonsurvivors were compared, and the chemokine levels were correlated with prognostic disease severity scores and various laboratory parameters.
resultsExtremely high levels of all chemokines were measured in the children's acute-phase sera. These levels were significantly higher in nonsurvivors compared with survivors and in patients with septic shock compared with patients with sepsis (P < 0.0001). The cutoff values of 65,407 pg/ml, 85,427 pg/ml and 460 pg/ml for monocyte chemoattractant protein, for IL-8 and for macrophage inflammatory protein 1alpha, respectively, all had 100% sensitivity and 94-98% specificity for nonsurvival. Chemokine levels correlated better with disease outcome and severity than tumor necrosis factor (TNF)-alpha and correlated similarly to interleukin (IL)-6. In available samples 24 hours after admission, a dramatic decrease of chemokine levels was seen.
conclusionInitial-phase serum levels of chemokines in patients with meningococcal sepsis can predict mortality and can correlate strongly with disease severity. Chemokines may play a key role in the pathophysiology of meningococcal disease and are potentially new targets for therapeutic approaches.
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