ArticleArthritis research & therapy2006
Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study.
Article in Arthritis research & therapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus.Annals of the rheumatic diseases · 2015Pooled it
- Meta-analysis reveals an association of PTPN22 C1858T with autoimmune diseases, which depends on the localization of the affected tissue.Genes and immunity · 2012Pooled it
- Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity.Immunology · 2012Pooled it
- PTPN22 C1858T and the risk of psoriasis: a meta-analysis.Molecular biology reports · 2012Pooled it
- Co-occurrence of endometriosis with psoriasis and psoriatic arthritis: Genetic insights (Review).Experimental and therapeutic medicine · 2025Review
- MTHFR C677T rs1801133 and TP53 Pro72Arg rs1042522 gene variants in South African Indian and Caucasian psoriatic arthritis patients.Genetics and molecular biology · 2025Article
- Association of Functional Polymorphism in Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) Gene with Vitiligo.Biomarker insights · 2020Article
- The Protein Tyrosine Phosphatase Nonreceptor 22 (Clinical medicine insights. Arthritis and musculoskeletal disorders · 2018Article
- PTPN22: the archetypal non-HLA autoimmunity gene.Nature reviews. Rheumatology · 2014Review
- Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.Annals of the rheumatic diseases · 2012Article
- Association between the PTPN22 +1858 C/T polymorphism and psoriatic arthritis.Arthritis research & therapy · 2011Article
- Single-nucleotide polymorphisms p53 G72C and Mdm2 T309G in patients with psoriasis, psoriatic arthritis, and SAPHO syndrome.Rheumatology international · 2010Article
- Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases.Seminars in immunopathology · 2010Review
- New insights into the pathogenesis and genetics of psoriatic arthritis.Nature clinical practice. Rheumatology · 2009Review
- Polymorphisms in the PTPN22 region are associated with psoriasis of early onset.The British journal of dermatology · 2008Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have implicated PTPN22 and tp53 in susceptibility to several autoimmune diseases, including rheumatoid arthritis, suggesting that these genes are important in maintaining immune homeostasis. Because autoimmune diseases may share similar susceptibility loci, investigation of these genes in psoriatic arthritis (PsA) is of potential relevance. As a result we investigated known coding polymorphisms in PTPN22 and tp53 in a homogenous Caucasian PsA cohort from Newfoundland, Canada and an admixed Caucasian PsA cohort from Toronto, Canada. We observed a moderate association of the R620W variant of PTPN22 with PsA in the Toronto population only. Because of the conflicting findings reported regarding the association of PTPN22 with PsA, further studies in other PsA populations are warranted.
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Registered trials
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