Evidence map›Paper›PMID 16506439›Full record

GuidelineDrugs & aging2005

Guidelines for the treatment of Alzheimer's disease from the Italian Association of Psychogeriatrics.

Carlo Caltagirone, Angelo Bianchetti, Monica Di Luca, Patrizia Mecocci, Alessandro Padovani, Elvezio Pirfo, Pierluigi Scapicchio, Umberto Senin, Marco Trabucchi, Massimo Musicco and 1 more

Abstract readPractice Guideline
PubMed Publisher
In one paragraph

Guideline in Drugs & aging, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. A Systematic Review of Practice Guidelines and Recommendations for Discontinuation of Cholinesterase Inhibitors in Dementia.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2018
    Pooled it
  3. Review
  4. Brand new norms for a good old test: Northern Italy normative study of MiniMental State Examination.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Consensus statement on dementia education and training in Europe.The journal of nutrition, health & aging · 2010
    Article
  11. Article
  12. Article
  13. Article
  14. Ethical questions in the treatment of subjects with dementia. Part I. Respecting autonomy: awareness, competence and behavioural disorders.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2007
    Article
  15. Review
  16. Treatment guidelines for Alzheimer's disease: redefining perceptions in primary care.Primary care companion to the Journal of clinical psychiatry · 2007
    Article
  17. Article
  18. Article
  19. Donepezil in severe Alzheimer's disease.American journal of Alzheimer's disease and other dementias
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Carlo CaltagironeFondazione IRCCS, Santa Lucia, Università Tor Vergata, Rome, Italy. c.caltagirone@hsantalucia.it
Angelo Bianchetti
Monica Di Luca
Patrizia Mecocci
Alessandro Padovani
Elvezio Pirfo
Pierluigi Scapicchio
Umberto Senin
Marco Trabucchi
Massimo Musicco
Italian Association of Psychogeriatrics
University of Perugia · ITFondazione Santa Lucia · ITInstitute of Biomedical Technologies · ITUniversità Cattolica del Sacro Cuore · ITUniversity of Brescia · ITUniversity of Milan · ITUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A committee of experts from the Italian Association of Psychogeriatrics compiled the following report, which was then approved by a Steering Committee (comprising 20 specialists in neurology, psychiatry or geriatrics) from the Association and by two Alzheimer associations representing patients and families: the Italian Association for Alzheimer's Disease and the Italian Federation for Alzheimer's Disease. The report is based on a comprehensive review of the scientific literature on the treatment of Alzheimer's disease, discusses methodological aspects of dementia management, and details the limitations of current therapies. These guidelines are, in general, consistent with the principles of evidence-based medicine; however, for some controversial or poorly investigated issues, the guidelines integrate scientific evidence with experience and opinions from experts working in the clinical setting. In particular, the clinical experience of experts has been used to define recommendations for starting and interrupting pharmacotherapy, and to critically review evidence about the efficacy of non-pharmacological interventions. The principal pharmacotherapeutic interventions covered in the guidelines are acetylcholinesterase inhibitors (donepezil, galantamine, rivastigmine, and tacrine) and memantine. The main non-pharmacological interventions reviewed are memory training, reality orientation therapy, and combined non-pharmacological interventions. Other issues covered are opportunities for Alzheimer's disease prevention, various modalities of care, and the treatment of comorbidities.

Indexed as

AgedAlzheimer DiseaseCholinesterase InhibitorsClinical Trials as TopicDepressive DisorderExcitatory Amino Acid AntagonistsHumansItalyMemantinePsychotherapyCholinesterase InhibitorsExcitatory Amino Acid AntagonistsMemantine

Identifiers

PMID16506439
OpenAlexW2057760116

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.