ReviewChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2006
Chromatin dynamics and the evolution of alternate promoter states.
Review in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Machine learning methods for gene regulatory network inference.Briefings in bioinformatics · 2025Review
- Transcriptional Bursting and Co-bursting Regulation by Steroid Hormone Release Pattern and Transcription Factor Mobility.Molecular cell · 2019Article
- Discontinuous transcription.Nucleus (Austin, Tex.) · 2018Review
- Genomic effects of glucocorticoids.Protoplasma · 2017Review
- Structure of silent transcription intervals and noise characteristics of mammalian genes.Molecular systems biology · 2015Article
- Direct observation of frequency modulated transcription in single cells using light activation.eLife · 2013Article
- Eukaryotic transcriptional dynamics: from single molecules to cell populations.Nature reviews. Genetics · 2013Review
- Glucocorticoid receptor and histone deacetylase-2 mediate dexamethasone-induced repression of MUC5AC gene expression.American journal of respiratory cell and molecular biology · 2012Article
- Impact of chromatin structure on PR signaling: transition from local to global analysis.Molecular and cellular endocrinology · 2012Review
- Analytical distribution and tunability of noise in a model of promoter progress.Biophysical journal · 2012Article
- Quantitative analysis of genome-wide chromatin remodeling.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Assembly of the transcription machinery: ordered and stable, random and dynamic, or both?Chromosoma · 2011Review
- What do expression dynamics tell us about the mechanism of transcription?Current opinion in genetics & development · 2011Review
- Dynamic interaction of HDAC1 with a glucocorticoid receptor-regulated gene is modulated by the activity state of the promoter.The Journal of biological chemistry · 2011Article
- Article
- Insights on glucocorticoid receptor activity modulation through the binding of rigid steroids.PloS one · 2010Article
- Nucleosome positioning: how is it established, and why does it matter?Developmental biology · 2010Review
- On the spontaneous stochastic dynamics of a single gene: complexity of the molecular interplay at the promoter.BMC systems biology · 2010Article
- Genome-wide mechanisms of nuclear receptor action.Trends in endocrinology and metabolism: TEM · 2010Review
- Chromatin poises miRNA- and protein-coding genes for expression.Genome research · 2009Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Eucaryotic gene transcriptional switches utilize changes both in the activity and composition of soluble transcription factor complexes, and epigenetic modifications to the chromatin template. Until recently, alternate states of promoter activity have been associated with the assembly of relatively stable multiprotein complexes on target genes, with transitions in the composition of these complexes occurring on the time scale of minutes or hours. The development of living cell techniques to characterize transcription factor function in real time has led to an alternate view of highly dynamic protein/template interactions. In addition, emerging evidence suggests that energy-dependent processes contribute significantly to the rapid movement of proteins in living cells, and to the exchange of sequence-specific DNA-binding proteins with regulatory elements. Potential mechanisms involved in the unexpectedly rapid flux of factor/template interactions are discussed in the context of a "return-to-template" model for transcription factor function.
Indexed as
Identifiers
16506100What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.