ArticleCell regulation1991
Modulation of intercellular adherens-type junctions and tyrosine phosphorylation of their components in RSV-transformed cultured chick lens cells.
Article in Cell regulation, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 161 citations in OpenAlex.
- E-Cadherin: A conductor of cellular signaling.Current opinion in cell biology · 2025Review
- Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation.Mediators of inflammation · 2015Review
- Blood cells and endothelial barrier function.Tissue barriers · 2015Article
- Phosphatase regulation of intercellular junctions.Tissue barriers · 2013Review
- Distinct roles for N-Cadherin linked c-Src and fyn kinases in lens development.Developmental dynamics : an official publication of the American Association of Anatomists · 2013Article
- The role of MAPK in drug-induced kidney injury.Journal of signal transduction · 2012Article
- Sodium orthovanadate effect on outflow facility and intraocular pressure in live monkeys.Experimental eye research · 2010Article
- The regulation of vascular endothelial growth factor-induced microvascular permeability requires Rac and reactive oxygen species.The Journal of biological chemistry · 2009Article
- Occludin phosphorylation in regulation of epithelial tight junctions.Annals of the New York Academy of Sciences · 2009Article
- E-cadherin adhesion activates c-Src signaling at cell-cell contacts.Molecular biology of the cell · 2007Article
- Not so simple: the complexity of phosphotyrosine signaling at cadherin adhesive contacts.Journal of molecular medicine (Berlin, Germany) · 2007Review
- Cell cycle regulation in the developing lens.Seminars in cell & developmental biology · 2006Review
- VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts.The EMBO journal · 2002Article
- Article
- PTPmu regulates N-cadherin-dependent neurite outgrowth.The Journal of cell biology · 1999Article
- Regulators of vascular permeability: potential sites for intervention in the treatment of macular edema.Documenta ophthalmologica. Advances in ophthalmology · 1999Review
- Dynamic interaction of PTPmu with multiple cadherins in vivo.The Journal of cell biology · 1998Article
- Src and Ras are involved in separate pathways in epithelial cell scattering.The EMBO journal · 1997Article
- Cross talk between adhesion molecules: control of N-cadherin activity by intracellular signals elicited by beta1 and beta3 integrins in migrating neural crest cells.The Journal of cell biology · 1997Article
- Characterization of pinin, a novel protein associated with the desmosome-intermediate filament complex.The Journal of cell biology · 1996Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transformation of cultured chick lens epithelial cells with a temperature-sensitive mutant of Rous sarcoma virus (tsRSV) leads to radical changes in cell shape and interactions. When cultured at the restrictive temperature (42 degrees C), the transformed cells largely retained epithelial morphology and intercellular adherens junctions (AJ), whereas on switch to the permissive temperature (37 degrees C) they rapidly became fibroblastoid, their AJ deteriorated, and cell adhesion molecules (A-CAM) (N-cadherin) largely disappeared from intercellular contact sites. The microfilament system that was primarily associated with these junctions was markedly rearranged on shift to 37 degrees C and remained associated mainly with cell-substrate focal contacts. These apparent changes in intercellular AJ were not accompanied by significant alterations in the cellular content of several junction-associated molecules, including A-CAM, vinculin, and talin. Immunolabeling with phosphotyrosine-specific antibodies indicated that both cell-substrate and intercellular AJ were the major cellular targets for the pp60v-src tyrosine-specific protein kinase. It was further shown that intercellular AJ components serve as substrates to tyrosine kinases also in nontransformed lens cells, because the addition of a combination of vanadate and H2O2--which are potent inhibitors of protein tyrosine phosphatases--leads to a remarkable accumulation of immunoreactive phosphotyrosine-containing proteins in these junctions. This finding suggests that intercellular junctions are major sites of action of protein tyrosine kinases and that protein tyrosine phosphatases play a major role in the regulation of phosphotyrosine levels in AJ of both normal and RSV-transformed cells.
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