ArticleProceedings of the National Academy of Sciences of the United States of America2006
Sodium channel genes and the evolution of diversity in communication signals of electric fishes: convergent molecular evolution.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.
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Who cites it
76 citing papers in PubMed, 1 synthesis or guideline pooled it, 157 citations in OpenAlex.
- The probability of genetic parallelism and convergence in natural populations.Proceedings. Biological sciences · 2012Pooled it
- The genetic foundations of convergent traits.Nature reviews. Genetics · 2026Review
- Developmental and evolutionary changes in sensorimotor integration to maintain coordination of corollary discharge and afferent input in electric fish.Current biology : CB · 2026Article
- The electrogenicity of the NaeLife · 2025Article
- A chromosome-level genome assembly of Electrophorus voltai, a species of electric eel.Scientific data · 2025Article
- Gene expression correlates and mechanistic insights into electric organ discharge duration changes in mormyrid electric fish.The Journal of experimental biology · 2025Article
- Transcriptomic Data Reveal Divergent Paths of Chitinase Evolution Underlying Dietary Convergence in Anteaters and Pangolins.Genome biology and evolution · 2025Article
- Organization of the stalk system on electrocytes in mormyrid weakly electric fish Campylomormyrus compressirostris.Cell and tissue research · 2025Article
- Model organisms and systems in neuroethology: one hundred years of history and a look into the future.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- Ecologically mediated differences in electric organ discharge drive evolution in a sodium channel gene in South American electric fishes.Biology letters · 2024Article
- A chromosome-level genome of electric catfish (Marine life science & technology · 2024Article
- Evolution of androgen receptors contributes to species variation in androgenic regulation of communication signals in electric fishes.Molecular and cellular endocrinology · 2023Article
- A homology guide for Pacific salmon genusEcology and evolution · 2023Article
- Molecular evolution of the ependymin-related gene epdl2 in African weakly electric fish.G3 (Bethesda, Md.) · 2023Article
- A New Hope: A Hermaphroditic Nematode Enables Analysis of a Recent Whole Genome Duplication Event.Genome biology and evolution · 2022Article
- Evolution of central neural circuits: state of the art and perspectives.Nature reviews. Neuroscience · 2022Review
- An atlas of fish genome evolution reveals delayed rediploidization following the teleost whole-genome duplication.Genome research · 2022Article
- Divergent cis-regulatory evolution underlies the convergent loss of sodium channel expression in electric fish.Science advances · 2022Article
- Review
- Advancing human disease research with fish evolutionary mutant models.Trends in genetics : TIG · 2022Review
16 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 2 countries.
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Abstract
We investigated whether the evolution of electric organs and electric signal diversity in two independently evolved lineages of electric fishes was accompanied by convergent changes on the molecular level. We found that a sodium channel gene (Na(v)1.4a) that is expressed in muscle in nonelectric fishes has lost its expression in muscle and is expressed instead in the evolutionarily novel electric organ in both lineages of electric fishes. This gene appears to be evolving under positive selection in both lineages, facilitated by its restricted expression in the electric organ. This view is reinforced by the lack of evidence for selection on this gene in one electric species in which expression of this gene is retained in muscle. Amino acid replacements occur convergently in domains that influence channel inactivation, a key trait for shaping electric communication signals. Some amino acid replacements occur at or adjacent to sites at which disease-causing mutations have been mapped in human sodium channel genes, emphasizing that these replacements occur in functionally important domains. Selection appears to have acted on the final step in channel inactivation, but complementarily on the inactivation "ball" in one lineage, and its receptor site in the other lineage. Thus, changes in the expression and sequence of the same gene are associated with the independent evolution of signal complexity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.