Evidence map›Paper›PMID 16505299›Full record

Trial reportNeurology2006

Weight-supported treadmill vs over-ground training for walking after acute incomplete SCI.

B Dobkin, D Apple, H Barbeau, M Basso, A Behrman, D Deforge, J Ditunno, G Dudley, R Elashoff, L Fugate and 4 more

4 registry-linked trialsOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 174 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
174citing papers in PubMed, 10 pooled it
42.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02749357 nacompletednot on this mapstarted 2016, after this paper: background citation

Effect of Different Programs of Robotic Assisted Gait Training in Individuals With Chronic Motor Incomplete Spinal Cord Injury.

TypeinterventionalSponsorInstituto Nacional de RehabilitacionRan2016 to 2021Enrolled44ConditionsSpinal Cord InjuriesArms30 minutes Lokomat, 60 minutes Lokomat
NCT03669302 naterminatednot on this mapstarted 2018, after this paper: background citation

Activity-Dependent Transspinal Stimulation for Recovery of Walking Ability After Spinal Cord Injury

TypeinterventionalSponsorCity University of New YorkRan2018 to 2021Enrolled10ConditionsSpinal Cord Injuries, Paraplegia, Spinal, Tetraplegia/Tetraparesis, Paraplegia, SpasticArmsRobotic gait training, Robotic gait training and low-frequency transspinal stimulation, Robotic gait training and high-frequency transspinal stimulation
NCT03979742 phase2terminatednot on this mapstarted 2022, after this paper: background citation

A Randomized Controlled Phase II, Two-Arm Study of Umbilical Cord Blood Cell Transplant (MC001) Into Injured Spinal Cord Followed by the Locomotor Training for Patients with Chronic Complete Spinal Cord Injuries (SCI).

TypeinterventionalSponsorStemCyte, Inc.Ran2022 to 2024Enrolled6ConditionsSpinal Cord InjuriesArmsUmbilical Cord Blood Mononuclear Cell, Locomotor Training
NCT04807764 nacompletednot on this mapstarted 2021, after this paper: background citation

Priming With High-Frequency Trans-spinal Stimulation to Augment Locomotor Benefits in Spinal Cord Injury

TypeinterventionalSponsorCity University of New YorkRan2021 to 2024Enrolled14ConditionsSpinal Cord Injuries, Paraplegia, Spinal, Tetraplegia/Tetraparesis, Paraplegia, SpasticArmsStanding transspinal stimulation followed by robotic gait training, Lying transspinal stimulation followed by robotic gait training, Standing sham transspinal stimulation followed by robotic gait training
3 · Its place in the literature

Who cites it

174 citing papers in PubMed, 10 syntheses or guidelines pooled it, 478 citations in OpenAlex.

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  9. Locomotor training for walking after spinal cord injury.The Cochrane database of systematic reviews · 2012
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  14. Exploiting telerobotics for sensorimotor rehabilitation: a locomotor embodiment.Journal of neuroengineering and rehabilitation · 2021
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114 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

B DobkinDepartment of Neurology, University of California Los Angeles, Neurologic Rehabilitation and Research Program, Reed Neurologic Research Center, Los Angeles, CA 90095, USA. bdobkin@mednet.ucla.edu
D Apple
H Barbeau
M Basso
A Behrman
D Deforge
J Ditunno
G Dudley
R Elashoff
L Fugate
S Harkema
M Saulino
M Scott
Spinal Cord Injury Locomotor Trial Group
Urologic Research Institute · USUniversity of California, Los Angeles · US

Funding

YALE CENTER FOR THE: LEARNING &ATTENTIONP41RR013642 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARER, ELAINE L · 1998 to 2011
$21.9M
WESTERN REHABILITATION RESEARCH NETWORKR24HD039629 · NICHD · UNIVERSITY OF WASHINGTON · PI ANDERSON, MARJORIE E · 2000 to 2004
$4.8M
LOCOMOTOR THERAPY TRIAL FOR SPINAL CORD INJURYU01HD037439 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DOBKIN, BRUCE HARVEY · 1999 to 2003
$3.3M
NCRR NIH HHS P41 RR013642NICHD NIH HHS K01 HD013848NICHD NIH HHS R01 HD37439NICHD NIH HHS R24 HD039629NICHD NIH HHS R24 HD39629NICHD NIH HHS U01 HD037439
6 · The paper itself

Abstract

objectiveTo compare the efficacy of step training with body weight support on a treadmill (BWSTT) with over-ground practice to the efficacy of a defined over-ground mobility therapy (CONT) in patients with incomplete spinal cord injury (SCI) admitted for inpatient rehabilitation.

methodsA total of 146 subjects from six regional centers within 8 weeks of SCI were entered in a single-blinded, multicenter, randomized clinical trial (MRCT). Subjects were graded on the American Spinal Injury Association Impairment Scale (ASIA) as B, C, or D with levels from C5 to L3 and had a Functional Independence Measure for locomotion (FIM-L) score < 4. They received 12 weeks of equal time of BWSTT or CONT. Primary outcomes were FIM-L for ASIA B and C subjects and walking speed for ASIA C and D subjects 6 months after SCI.

resultsNo significant differences were found at entry between treatment groups or at 6 months for FIM-L (n = 108) or walking speed and distance (n = 72). In the upper motor neuron (UMN) subjects, 35% of ASIA B, 92% of ASIA C, and all ASIA D subjects walked independently. Velocities for UMN ASIA C and D subjects were not significantly different for BWSTT (1.1 +/- 0.6 m/s, n = 30) and CONT (1.1 +/- 0.7, n = 25) groups.

conclusionsThe physical therapy strategies of body weight support on a treadmill and defined overground mobility therapy did not produce different outcomes. This finding was partly due to the unexpectedly high percentage of American Spinal Injury Association C subjects who achieved functional walking speeds, irrespective of treatment. The results provide new insight into disability after incomplete spinal cord injury and affirm the importance of the multicenter, randomized clinical trial to test rehabilitation strategies.

Indexed as

Exercise TestAdolescentAdultAgedExerciseHumansLocomotionMiddle AgedMotor ActivitySpinal Cord InjuriesTreatment OutcomeWalkingWeight-Bearing

Identifiers

PMID16505299
PMCPMC4102098
OpenAlexW3208416847

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.