ReviewJournal of clinical pathology2006
In stent restenosis: bane of the stent era.
Review in Journal of clinical pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
85 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Influences of Stent Design on In-Stent Restenosis and Major Cardiac Outcomes: A Scoping Review and Meta-Analysis.Cardiovascular engineering and technology · 2022Pooled it
- Efficacy and safety of polymer-free stent versus polymer-permanent drug-eluting stent in patients with acute coronary syndrome: a meta-analysis of randomized control trials.BMC cardiovascular disorders · 2017Pooled it
- Cilostazol is associated with improved outcomes after peripheral endovascular interventions.Journal of vascular surgery · 2014Pooled it
- Xiongshao for restenosis after percutaneous coronary intervention in patients with coronary heart disease.The Cochrane database of systematic reviews · 2013Pooled it
- Computational Corrosion Modeling for Biodegradable Magnesium Alloy Stents: Progress, Challenges, and Future Directions.Annals of biomedical engineering · 2026Review
- A computational model of coronary arteries with in-stent restenosis coupling hemodynamics and pharmacokinetics with growth mechanics.Scientific reports · 2025Article
- Effect of Yak Skin Gelatin with Different Molecular Weights on the Properties of Gelatin/Polymethyl Vinyl Ether-ACS omega · 2025Article
- The DERIVO 2 Heal Embolization Device in the Treatment of Ruptured and Unruptured Intracranial Aneurysms: a Retrospective Multicenter Study.Clinical neuroradiology · 2025Article
- Research progress in the regulation of endothelial cells and smooth muscle cells using a micro-nanostructure.Biomedical engineering online · 2025Review
- A risk prediction nomogram for in-stent restenosis in patients with coronary heart disease: first exploratory analysis based on the substrate materials of drug-eluting stents.Frontiers in cardiovascular medicine · 2025Article
- Smart materials strategy for vascular challenges targeting in-stent restenosis: a critical review.Regenerative biomaterials · 2025Review
- Deforming Patient-Specific Models of Vascular Anatomies to Represent Stent Implantation via Extended Position Based Dynamics.Cardiovascular engineering and technology · 2024Article
- Manufacturing, Processing, and Characterization of Self-Expanding Metallic Stents: A Comprehensive Review.Bioengineering (Basel, Switzerland) · 2024Review
- Remote Ischemic Preconditioning Before Drug-Coated Balloon Implantation can Improve the Long-Term Prognosis of Patients with CAD.Reviews in cardiovascular medicine · 2024Article
- In-Stent Restenosis Overview: From Intravascular Imaging to Optimal Percutaneous Coronary Intervention Management.Medicina (Kaunas, Lithuania) · 2024Review
- Preclinical evaluation of the functionality of a polymer-coated sirolimuseluting stent in pigs.Acta cirurgica brasileira · 2024Article
- Investigating the relationship between the VNTR variant of the interleukin-1 receptor antagonist gene and coronary in-stent restenosis.Molecular biology reports · 2023Article
- Experimental Liver Cirrhosis Inhibits Restenosis after Balloon Angioplasty.International journal of molecular sciences · 2023Article
- Noncoding RNAs in Vascular Cell Biology and Restenosis.Biology · 2022Review
- Circular RNAs in cardiovascular diseases.Pharmacology & therapeutics · 2022Review
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The long term outcome of stent implantation is affected by a process called in stent restenosis (ISR). Multiple contributory factors have been identified, but clear understanding of the overall underlying mechanism remains an enigma. ISR progresses through several different phases and involves numerous cellular and molecular constituents. Platelets and macrophages play a central role via vascular smooth muscle cell migration and proliferation in the intima to produce neointimal hyperplasia, which is pathognomic of ISR. Increased extracellular matrix formation appears to form the bulk of the neointimal hyperplasia tissue. Emerging evidence of the role of inflammatory cytokines and suppressors of cytokine signalling make this an exciting and novel field of antirestenosis research. Activation of Akt pathway triggered by mechanical stretch may also be a contributory factor to ISR formation. Prevention of ISR appears to be a multipronged attack as no therapeutic "magic bullet" exists to block all the processes in one go.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.