ArticleThe Journal of cell biology2006
Assembling an intermediate filament network by dynamic cotranslation.
Article in The Journal of cell biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 85 citations in OpenAlex.
- RNA-binding proteins and ribonucleoproteins as determinants of immunity.Nature reviews. Immunology · 2026Review
- Posttranscriptional regulation of neurofilament proteins and tau in health and disease.Brain research bulletin · 2023Review
- Cotranslational Mechanisms of Protein Biogenesis and Complex Assembly in Eukaryotes.Annual review of biomedical data science · 2022Review
- Antigenicity Preservation Is Related to Tissue Characteristics and the Post-Mortem Interval: Immunohistochemical Study and Literature Review.Healthcare (Basel, Switzerland) · 2022Article
- Mechanisms of Cotranslational Protein Maturation in Bacteria.Frontiers in molecular biosciences · 2021Review
- Distribution of disease-causing germline mutations in coiled-coils implies an important role of their N-terminal region.Scientific reports · 2020Article
- Cytoskeletal and extracellular matrix proteins as markers for metastatic triple negative breast cancer.The Journal of international medical research · 2019Article
- A microtranslatome coordinately regulates sodium and potassium currents in the human heart.eLife · 2019Article
- Translation factor mRNA granules direct protein synthetic capacity to regions of polarized growth.The Journal of cell biology · 2019Article
- Fluorescence Imaging Methods to Investigate Translation in Single Cells.Cold Spring Harbor perspectives in biology · 2019Review
- Assembly Kinetics of Vimentin Tetramers to Unit-Length Filaments: A Stopped-Flow Study.Biophysical journal · 2018Article
- Intracellular Motility of Intermediate Filaments.Cold Spring Harbor perspectives in biology · 2017Review
- Visualization of single endogenous polysomes reveals the dynamics of translation in live human cells.The Journal of cell biology · 2016Article
- Profilin connects actin assembly with microtubule dynamics.Molecular biology of the cell · 2016Article
- Article
- RNA imaging in living cells - methods and applications.RNA biology · 2014Review
- Efficient retrograde transport of pseudorabies virus within neurons requires local protein synthesis in axons.Cell host & microbe · 2013Article
- Imaging translation in single cells using fluorescent microscopy.Cold Spring Harbor perspectives in biology · 2012Review
- Post-transcriptional regulation of fukutin in an astrocytoma cell line.International journal of experimental pathology · 2012Article
- Inroads into the structure and function of intermediate filament networks.Journal of structural biology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
We have been able to observe the dynamic interactions between a specific messenger RNA (mRNA) and its protein product in vivo by studying the synthesis and assembly of peripherin intermediate filaments (IFs). The results show that peripherin mRNA-containing particles (messenger ribonucleoproteins [mRNPs]) move mainly along microtubules (MT). These mRNPs are translationally silent, initiating translation when they cease moving. Many peripherin mRNPs contain multiple mRNAs, possibly amplifying the total amount of protein synthesized within these "translation factories." This mRNA clustering is dependent on MT, regulatory sequences within the RNA and the nascent protein. Peripherin is cotranslationally assembled into insoluble, nonfilamentous particles that are precursors to the long IF that form extensive cytoskeletal networks. The results show that the motility and targeting of peripherin mRNPs, their translational control, and the assembly of an IF cytoskeletal system are linked together in a process we have termed dynamic cotranslation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.