ArticleThe Journal of cell biology2006
Role of the kinetochore/cell cycle checkpoint protein ZW10 in interphase cytoplasmic dynein function.
Article in The Journal of cell biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 55 citations in OpenAlex.
- ZW10: an emerging orchestrator of organelle dynamics during the cell division cycle.Journal of molecular cell biology · 2024Review
- Effect of Hydroxyurea on Morphology, Proliferation, and Protein Expression onInternational journal of molecular sciences · 2024Article
- Comprehensive analysis of 5-hydroxymethylcytosine in zw10 kinetochore protein as a promising biomarker for screening and diagnosis of early colorectal cancer.Clinical and translational medicine · 2020Article
- Genetic interaction between two insulin-dependent diabetes susceptibility loci, Idd2 and Idd13, in determining immunoregulatory DN T cell proportion.Immunogenetics · 2018Article
- Rs2459976 inOncotarget · 2018Article
- The RZZ complex requires the N-terminus of KNL1 to mediate optimal Mad1 kinetochore localization in human cells.Open biology · 2015Article
- Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders.Frontiers in neuroscience · 2015Review
- Moonlighting functions of the NRZ (mammalian Dsl1) complex.Frontiers in cell and developmental biology · 2014Review
- Protein adaptation: mitotic functions for membrane trafficking proteins.Nature reviews. Molecular cell biology · 2013Review
- What Drosophila spermatocytes tell us about the mechanisms underlying cytokinesis.Cytoskeleton (Hoboken, N.J.) · 2012Review
- The Drosophila RZZ complex - roles in membrane trafficking and cytokinesis.Journal of cell science · 2012Article
- Multiple modes of cytoplasmic dynein regulation.Nature cell biology · 2012Article
- Adenovirus recruits dynein by an evolutionary novel mechanism involving direct binding to pH-primed hexon.Viruses · 2011Review
- The Dsl1 protein tethering complex is a resident endoplasmic reticulum complex, which interacts with five soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptors (SNAREs): implications for fusion and fusion regulation.The Journal of biological chemistry · 2011Article
- Polo-like kinase1 is required for recruitment of dynein to kinetochores during mitosis.The Journal of biological chemistry · 2011Article
- Golgi positioning.Cold Spring Harbor perspectives in biology · 2011Review
- Recruitment of dynein to late endosomes and lysosomes through light intermediate chains.Molecular biology of the cell · 2011Article
- Development and application of in vivo molecular traps reveals that dynein light chain occupancy differentially affects dynein-mediated processes.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Adenovirus transport via direct interaction of cytoplasmic dynein with the viral capsid hexon subunit.Cell host & microbe · 2009Article
- Regulators of the cytoplasmic dynein motor.Nature reviews. Molecular cell biology · 2009Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Zeste white 10 (ZW10) is a mitotic checkpoint protein and the anchor for cytoplasmic dynein at mitotic kinetochores, though it is expressed throughout the cell cycle. We find that ZW10 localizes to pericentriolar membranous structures during interphase and cosediments with Golgi membranes. Dominant-negative ZW10, anti-ZW10 antibody, and ZW10 RNA interference (RNAi) caused Golgi dispersal. ZW10 RNAi also dispersed endosomes and lysosomes. Live imaging of Golgi, endosomal, and lysosomal markers after reduced ZW10 expression showed a specific decrease in the frequency of minus end-directed movements. Golgi membrane-associated dynein was markedly decreased, suggesting a role for ZW10 in dynein cargo binding during interphase. We also find ZW10 enriched at the leading edge of migrating fibroblasts, suggesting that ZW10 serves as a general regulator of dynein function throughout the cell cycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.