ArticleThe Journal of experimental medicine2006
A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition.
Article in The Journal of experimental medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed.
- γδ T cell receptor recognition of CD1d in a lipid-independent manner.Nature communications · 2025Article
- Three-Dimensional Modeling ofAntibodies (Basel, Switzerland) · 2025Article
- Sensing mycobacteria through unconventional pathways.The Journal of clinical investigation · 2025Article
- Invariant Natural Killer T lymphocytes as natural sensors for microbes: a two-edged sword in liver diseases.Frontiers in immunology · 2025Review
- Direct recognition of an intact foreign protein by an αβ T cell receptor.Nature communications · 2024Article
- Markers and makers of NKT17 cells.Experimental & molecular medicine · 2023Review
- A bispecific T cell engager recruits both type 1 NKT and Vγ9Vδ2-T cells for the treatment of CD1d-expressing hematological malignancies.Cell reports. Medicine · 2023Article
- Article
- Benzofuran sulfonates and small self-lipid antigens activate type II NKT cells via CD1d.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Lipid antigens in bile from patients with chronic liver diseases activate natural killer T cells.Clinical and experimental immunology · 2021Article
- In Vivo Cytotoxicity by α-GalCer-transactivated NK Cells.Methods in molecular biology (Clifton, N.J.) · 2021Article
- A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response.Nature cancer · 2020Article
- Immune profiling of pediatric solid tumors.The Journal of clinical investigation · 2020Review
- Conservation of molecular and cellular phenotypes of invariant NKT cells between humans and non-human primates.Immunogenetics · 2019Article
- Diverse MR1-restricted T cells in mice and humans.Nature communications · 2019Article
- α-Lactosylceramide Protects Against iNKT-Mediated Murine Airway Hyperreactivity and Liver Injury Through Competitive Inhibition of Cd1d Binding.Frontiers in chemistry · 2019Article
- The ins and outs of type I iNKT cell development.Molecular immunology · 2019Review
- The Hypervariable Loops of Free TCRs Sample Multiple Distinct Metastable Conformations in Solution.Frontiers in molecular biosciences · 2018Article
- Key Residues at Third CDR3β Position Impact Structure and Antigen Recognition of Human Invariant NK TCRs.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Structure and function of the non-classical major histocompatibility complex molecule MR1.Immunogenetics · 2016Review
2 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors.
Funding
Abstract
Little is known regarding the basis for selection of the semi-invariant alphabeta T cell receptor (TCR) expressed by natural killer T (NKT) cells or how this mediates recognition of CD1d-glycolipid complexes. We have determined the structures of two human NKT TCRs that differ in their CDR3beta composition and length. Both TCRs contain a conserved, positively charged pocket at the ligand interface that is lined by residues from the invariant TCR alpha- and semi-invariant beta-chains. The cavity is centrally located and ideally suited to interact with the exposed glycosyl head group of glycolipid antigens. Sequences common to mouse and human invariant NKT TCRs reveal a contiguous conserved "hot spot" that provides a basis for the reactivity of NKT cells across species. Structural and functional data suggest that the CDR3beta loop provides a plasticity mechanism that accommodates recognition of a variety of glycolipid antigens presented by CD1d. We propose a model of NKT TCR-CD1d-glycolipid interaction in which the invariant CDR3alpha loop is predicted to play a major role in determining the inherent bias toward CD1d. The findings define a structural basis for the selection of the semi-invariant alphabeta TCR and the unique antigen specificity of NKT cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.