Evidence map›Paper›PMID 16505129›Full record

Trial reportThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2006

Depressive symptom deterioration in a large primary care-based elderly cohort.

Wayne J Katon, Ming-Yu Fan, Elizabeth H B Lin, Jürgen Unützer

Abstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Collaborative care for depression and anxiety problems.The Cochrane database of systematic reviews · 2012
    Pooled it
  2. Trial
  3. Trial
  4. Heterogeneity in the three-year course of major depression among older adults.International journal of geriatric psychiatry · 2016
    Article
  5. A Review of Psychostimulants for Adults With Depression.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2015
    Article
  6. Course of depression and mortality among older primary care patients.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2012
    Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Wayne J KatonDepartment of Psychiatry & Behavioral Sciences, University of Washington School of Medicine, Seattle, 98195, USA. wkaton@u.washington.edu
Ming-Yu Fan
Elizabeth H B Lin
Jürgen Unützer

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe purpose of this study is to examine the incidence and clinical predictors of symptom deterioration in depressed elderly patients who have responded to treatment in primary care.

methodA cohort study of 901 older adults from 18 primary care clinics in five states who met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria for major depression and/or dysthymia at baseline interview, had participated in a trial of collaborative care for depression compared to usual care, and had improved to the point of no longer meeting criteria for major depression at 12 months were observed for one year (18 and 24 months) after enrolling in the original study.

resultsA total of 40% of patients met criteria for significant depressive symptom deterioration over the 12- to 24-month observational period. Among usual-care patients, higher initial severity of depression and a higher number of residual DSM-IV depressive symptoms at 12 months were significant predictors of symptom deterioration. No variables predicted symptom deterioration in intervention patients.

conclusionsThere is a high rate of symptom deterioration among elderly patients in primary care who are treated for depression. Efforts to improve long-term outcomes of older patients with major depression and/or dysthymia should focus on providing more intensive treatment and follow up for patients with residual depressive symptoms.

Indexed as

Antidepressive AgentsCohort StudiesCooperative BehaviorCross-Sectional StudiesDepressionDiagnostic and Statistical Manual of Mental DisordersDisease ProgressionDysthymic DisorderFollow-Up StudiesHumansIncidenceMajor Depressive DisorderPatient Care ManagementPatient Care TeamPrimary Health CareProblem SolvingAntidepressive Agents

Identifiers

PMID16505129

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.