Trial reportThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2006
Response of emotional unawareness after stroke to antidepressant treatment.
Trial report in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- The Prevalence and Characteristics of Alexithymia in Adults Following Brain Injury: A Meta-Analysis.Neuropsychology review · 2021Pooled it
- Emotional processing in patients with single brain damage in the right hemisphere.BMC psychology · 2023Article
- Post-stroke alexithymia - a review.Postepy psychiatrii neurologii · 2021Review
- Therapeutic potential of fluoxetine in neurological disorders.CNS neuroscience & therapeutics · 2008Review
- It all happens between Toll receptors and caspase 1.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- The etiology of poststroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines.Molecular psychiatry · 2006Review
- Cognition and nondysphoric depression among adoptees at high risk for psychopathology.Comprehensive psychiatryArticle
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveUnawareness of impairment (anosognosia) is a phenomenon associated with right hemisphere lesions. Unawareness of emotion has rarely been studied.
methodsPatients (N = 50) with poststroke major depression were administered the Toronto, Ontario, Canada, Alexithymia Scale to assess impairment in identifying feelings (F1), describing feelings (F2), and externally oriented thinking (F3). After eight weeks of treatment with sertraline or fluoxetine, patients were reassessed.
resultsAlexithymia was significantly associated with right hemisphere lesions. Patients with alexithymia had a significant improvement in identifying and describing feelings, but not in externally oriented thinking. In addition, cognitive functions improved after antidepressant treatment in patients without alexithymia with left lesions only. On the contrary, functional activities of daily living and depressive symptoms improved both in patients with alexithymia and those without alexithymia.
conclusionsThe unawareness of emotions is a common impairment after right hemisphere stroke. This disorder may be significantly improved by antidepressant treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.