SynthesisBMC infectious diseases2006
Invasive fungal infections in neutropenic enterocolitis: a systematic analysis of pathogens, incidence, treatment and mortality in adult patients.
Synthesis in BMC infectious diseases, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Investigating neutropenic enterocolitis: a systematic review of case reports and clinical insights.BMC gastroenterology · 2025Pooled it
- Epidemiology, Risk Factors, and Outcomes of Neutropenic Enterocolitis in Onco-Hematological Patients According to Chemotherapy Regimen.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Neutropenic Enterocolitis: An Uncommon, but Fearsome Complication of Leukemia.Journal of hematology · 2023Review
- Article
- International Society of Paediatric Surgical Oncology (IPSO) Surgical Practice Guidelines.Ecancermedicalscience · 2022Article
- Immunosuppressed Patients with Clinically Diagnosed Invasive Fungal Infections: The Fungal Species Distribution, Antifungal Sensitivity and Associated Risk Factors in a Tertiary Hospital of Anhui Province.Infection and drug resistance · 2022Article
- Case reports of invasive mucormycosis associated neutropenic enterocolitis in leukemic children: diagnostic and treatment challenges and review of literature.BMC infectious diseases · 2021Review
- Early Diagnosis of Neutropenic Enterocolitis by Bedside Ultrasound in Hematological Malignancies: A Prospective Study.Journal of clinical medicine · 2021Article
- Fatal infection with enterocolitis from methicillin-resistantLeukemia research reports · 2021Article
- Neutropenic enterocolitis: A clinico-pathological review.World journal of gastrointestinal pathophysiology · 2019Article
- Acute cholecystitis in neutropenic patients.Annals of hepato-biliary-pancreatic surgery · 2019Article
- Diagnosis and management of gastrointestinal complications in adult cancer patients: 2017 updated evidence-based guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO).Annals of hematology · 2018Review
- Review
- Characteristic clinical features of Aspergillus appendicitis: Case report and literature review.World journal of gastroenterology · 2015Review
- Neutropenic enterocolitis: A continuing medical and surgical challenge.North American journal of medical sciences · 2010Article
- Ileocolonic mucormycosis in adult immunocompromised patients: a surgeon's perspective.World journal of gastroenterology · 2010Review
- Neutropenic enterocolitis: current issues in diagnosis and management.Current infectious disease reports · 2007Article
- Necrotizing enterocolitis in neutropenia and chemotherapy: a clinical update and old lessons relearned.Current gastroenterology reports · 2006Review
- Neutropenic Enterocolitis: A Rare Complication of Sacituzumab Govitecan.Case reports in oncologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeutropenic enterocolitis is a life-threatening complication most frequently occurring after intensive chemotherapy in acute leukaemias. Gramnegative bacteria constitute the most important group of causative pathogens. Fungi have also been reported, but their practical relevance remains unclear. The guidelines do not address concrete treatment recommendations for fungal neutropenic enterocolitis.
methodsHere, we conducted a metaanalysis to answer the questions: What are frequency and mortality of fungal neutropenic enterocolitis? Do frequencies and microbiological distribution of causative fungi support empirical antimycotic therapy? Do reported results of antimycotic therapy in documented fungal neutropenic enterocolitis help with the selection of appropriate drugs? Following a systematic search, we extracted and summarised all detail data from the complete literature.
resultsAmong 186 articles describing patients with neutropenic enterocolitis, we found 29 reports describing 53 patients with causative fungal pathogens. We found no randomised controlled trial, no good quality cohort study and no good quality case control study on the role of antifungal treatment. The pooled frequency of fungal neutropenic enterocolitis was 6.2% calculated from all 860 reported patients and 3.4% calculated from selected representative studies only. In 94% of the patients, Candida spp. were involved. The pooled mortality rate was 81.8%. Most authors did not report or perform antifungal therapy.
conclusionIn patients with neutropenic enterocolitis, fungal pathogens play a relevant, but secondary role compared to bacteria. Evidence concerning therapy is very poor, but epidemiological data from this study may provide helpful clues to select empiric antifungal therapy in neutropenic enterocolitis.
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