ArticleBMC genomics2006
Common features and interesting differences in transcriptional responses to secretion stress in the fungi Trichoderma reesei and Saccharomyces cerevisiae.
Article in BMC genomics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 98 citations in OpenAlex.
- Understanding Repression Under Secretion Stress inMicroorganisms · 2026Article
- Protein secretion and associated stress in industrially employed filamentous fungi.Applied microbiology and biotechnology · 2024Review
- Effect of the res2 transcription factor gene deletion on protein secretion and stress response in the hyperproducer strain Trichoderma reesei Rut-C30.BMC microbiology · 2023Article
- Transcriptomic and Functional Studies of the RGS Protein Rax1 in Aspergillus fumigatus.Pathogens (Basel, Switzerland) · 2019Article
- Signal peptide peptidase activity connects the unfolded protein response to plant defense suppression by Ustilago maydis.PLoS pathogens · 2019Article
- Omics for understanding the tolerant mechanism of Trichoderma asperellum TJ01 to organophosphorus pesticide dichlorvos.BMC genomics · 2018Article
- Integrated Translatome and Proteome: Approach for Accurate Portraying of Widespread Multifunctional Aspects ofFrontiers in microbiology · 2017Review
- The contribution of Aspergillus fumigatus stress responses to virulence and antifungal resistance.Journal of microbiology (Seoul, Korea) · 2016Review
- Effect of secretory pathway gene overexpression on secretion of a fluorescent reporter protein inFungal biology and biotechnology · 2016Article
- Genome wide analysis of protein production load in Trichoderma reesei.Biotechnology for biofuels · 2016Article
- Hansenula polymorpha Hac1p Is Critical to Protein N-Glycosylation Activity Modulation, as Revealed by Functional and Transcriptomic Analyses.Applied and environmental microbiology · 2015Article
- Function of a p24 Heterodimer in Morphogenesis and Protein Transport in Penicillium oxalicum.Scientific reports · 2015Article
- Two distinct classes of protein related to GTB and RRM are critical in the sclerotial metamorphosis process of Rhizoctonia solani AG-1 IA.Functional & integrative genomics · 2015Article
- Article
- Genome-wide analysis of the endoplasmic reticulum stress response during lignocellulase production in Neurospora crassa.Biotechnology for biofuels · 2015Article
- Investigation of protein secretion and secretion stress in Ashbya gossypii.BMC genomics · 2014Article
- Endoplasmic reticulum stress and fungal pathogenesis.Fungal biology reviews · 2014Article
- Deciphering the effect of the different N-glycosylation sites on the secretion, activity, and stability of cellobiohydrolase I from Trichoderma reesei.Applied and environmental microbiology · 2014Article
- Systems biological approaches towards understanding cellulase production by Trichoderma reesei.Journal of biotechnology · 2013Review
- Systems analysis of lactose metabolism in Trichoderma reesei identifies a lactose permease that is essential for cellulase induction.PloS one · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSecretion stress is caused by compromised folding, modification or transport of proteins in the secretory pathway. In fungi, induction of genes in response to secretion stress is mediated mainly by the unfolded protein response (UPR) pathway. This study aims at uncovering transcriptional responses occurring in the filamentous fungi Trichoderma reesei exposed to secretion stress and comparing these to those found in the yeast Saccharomyces cerevisiae.
resultsChemostat cultures of T. reesei expressing human tissue plasminogen activator (tPA) and batch bioreactor cultures treated with dithiothreitol (DTT) to prevent correct protein folding were analysed with cDNA subtraction and cDNA-amplified fragment length polymorphism (AFLP) experiments. ESTs corresponding to 457 unique genes putatively induced under secretion stress were isolated and the expression pattern of 60 genes was confirmed by Northern analysis. Expression of these genes was also studied in a strain over-expressing inositol-requiring enzyme 1 (IREI) protein, a sensor for the UPR pathway. To compare the data with that of S. cerevisiae, published transcriptome profiling data on various stress responses in S. cerevisiae was reanalysed. The genes up-regulated in response to secretion stress included a large number of secretion related genes in both organisms. In addition, analysis of T. reesei revealed up regulation of the cpc1 transcription factor gene and nucleosomal genes. The induction of the cpcA and histone gene H4 were shown to be induced also in cultures of Aspergillus nidulans treated with DTT.
conclusionAnalysis of the genes induced under secretion stress has revealed novel features in the stress response in T. reesei and in filamentous fungi. We have demonstrated that in addition to the previously rather well characterised induction of genes for many ER proteins or secretion related proteins also other types of responses exist.
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