ArticleBMC immunology2006
Sexual dimorphism in immune response genes as a function of puberty.
Article in BMC immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
51 citing papers in PubMed, 117 citations in OpenAlex.
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- Immunogenic Properties of a Novel Hepatitis A Vaccine Candidate Based on a Fast-Growing Viral Strain.Vaccines · 2025Article
- Granulocyte- Macrophage Colony-Stimulating Factor Reverses Immunosuppression Acutely Following a Traumatic Brain Injury and Hemorrhage Polytrauma in a Juvenile Male Rat Model.Journal of neurotrauma · 2024Article
- Sex-related differences in delayed doxorubicin-induced cardiac dysfunction in C57BL/6 mice.Archives of toxicology · 2024Article
- Sex Differences in the Frequencies of B and T Cell Subpopulations of Human Cord Blood.International journal of molecular sciences · 2023Article
- Sex hormones impact early maturation and immune response in the arteriovenous fistula mouse model.American journal of physiology. Heart and circulatory physiology · 2023Article
- Estimating the Prevalence and Factors Affecting the Shedding of Helminth Eggs in Irish Equine Populations.Animals : an open access journal from MDPI · 2023Article
- Sex, puberty, and the gut microbiome.Reproduction (Cambridge, England) · 2023Review
- Sex differences in a murine model of asthma are time and tissue compartment dependent.PloS one · 2023Article
- Serum amyloid A and metabolic disease: evidence for a critical role in chronic inflammatory conditions.Frontiers in cardiovascular medicine · 2023Review
- Placental macrophage responses to viral and bacterial ligands and the influence of fetal sex.iScience · 2022Article
- Estrogen, the Peripheral Immune System and Major Depression - A Reproductive Lifespan Perspective.Frontiers in behavioral neuroscience · 2022Review
- Complement Dependent Synaptic Reorganisation During Critical Periods of Brain Development and Risk for Psychiatric Disorder.Frontiers in neuroscience · 2022Review
- Sex Differences in Airway Remodeling and Inflammation: Clinical and Biological Factors.Frontiers in allergy · 2022Review
- Proteotyping of knockout mouse strains reveals sex- and strain-specific signatures in blood plasma.NPJ systems biology and applications · 2021Article
- Influence of Gestational Hormones on the Bacteria-Induced Cytokine Response in Periodontitis.Mediators of inflammation · 2021Review
- Masculinity and immune system efficacy in men.PloS one · 2020Article
- Sex as a Determinant of Responses to a Coronary Artery Disease Self-Antigen Identified by Immune-Peptidomics.Frontiers in immunology · 2020Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundAutoimmune diseases are more prevalent in females than in males, whereas males have higher mortality associated with infectious diseases. To increase our understanding of this sexual dimorphism in the immune system, we sought to identify and characterize inherent differences in immune response programs in the spleens of male and female mice before, during and after puberty.
resultsAfter the onset of puberty, female mice showed a higher expression of adaptive immune response genes, while males had a higher expression of innate immune genes. This result suggested a requirement for sex hormones. Using in vivo and in vitro assays in normal and mutant mouse strains, we found that reverse signaling through FasL was directly influenced by estrogen, with downstream consequences of increased CD8+ T cell-derived B cell help (via cytokines) and enhanced immunoglobulin production.
conclusionThese results demonstrate that sexual dimorphism in innate and adaptive immune genes is dependent on puberty. This study also revealed that estrogen influences immunoglobulin levels in post-pubertal female mice via the Fas-FasL pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.