ArticleBMC genomics2006
Further understanding human disease genes by comparing with housekeeping genes and other genes.
Article in BMC genomics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 4 of them syntheses that pooled it.
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Who cites it
66 citing papers in PubMed, 4 syntheses or guidelines pooled it, 149 citations in OpenAlex.
- A quantitative transcriptome reference map of the normal human brain.Neurogenetics · 2014Pooled it
- Identification of reference genes across physiological states for qRT-PCR through microarray meta-analysis.PloS one · 2011Pooled it
- Identification of human housekeeping genes and tissue-selective genes by microarray meta-analysis.PloS one · 2011Pooled it
- Gene- and evidence-based candidate gene selection for schizophrenia and gene feature analysis.Artificial intelligence in medicinePooled it
- Short-Term Evolutionary Features and Circadian Clock-Modulated Gene Expression Analysis ofInsects · 2025Article
- STIGMA: Single-cell tissue-specific gene prioritization using machine learning.American journal of human genetics · 2024Article
- Enhancing genomic mutation data storage optimization based on the compression of asymmetry of sparsity.Frontiers in genetics · 2023Article
- What are housekeeping genes?PLoS computational biology · 2022Article
- Locally Adjust Networks Based on Connectivity and Semantic Similarities for Disease Module Detection.Frontiers in genetics · 2021Article
- Defining housekeeping genes suitable for RNA-seq analysis of the human allograft kidney biopsy tissue.BMC medical genomics · 2019Article
- Dataset of differential gene expression between total normal human thyroid and histologically normal thyroid adjacent to papillary thyroid carcinoma.Data in brief · 2019Article
- In silico prediction of housekeeping long intergenic non-coding RNAs reveals HKlincR1 as an essential player in lung cancer cell survival.Scientific reports · 2019Article
- Mouse Models and Online Resources for Functional Analysis of Osteoporosis Genome-Wide Association Studies.Frontiers in endocrinology · 2019Review
- Article
- Analyzing of Molecular Networks for Human Diseases and Drug Discovery.Current topics in medicinal chemistry · 2018Review
- A molecular view of the normal human thyroid structure and function reconstructed from its reference transcriptome map.BMC genomics · 2017Article
- Systematic identification of human housekeeping genes possibly useful as references in gene expression studies.Molecular medicine reports · 2017Article
- Properties of human disease genes and the role of genes linked to Mendelian disorders in complex disease aetiology.Human molecular genetics · 2017Article
- Integrating network, sequence and functional features using machine learning approaches towards identification of novel Alzheimer genes.BMC genomics · 2016Article
- Purifying selection shapes the coincident SNP distribution of primate coding sequences.Scientific reports · 2016Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSeveral studies have compared various features of heritable disease genes with other so called non-disease genes, but they have yielded some conflicting results. A potential problem in those studies is that the non-disease genes contained a large number of essential genes--genes which are indispensable for humans to survive and reproduce. Since a functional disruption of an essential gene has fatal consequences, it's more reasonable to regard essential genes as extremely severe "disease" genes. Here we perform a comparative study on the features of human essential, disease, and other genes.
resultsIn the absence of a set of well defined human essential genes, we consider a set of 1,789 ubiquitously expressed human genes (UEHGs), also known as housekeeping genes, as an approximation. We demonstrate that UEHGs are very likely to contain a large proportion of essential genes. We show that the UEHGs, disease genes and other genes are different in their evolutionary conservation rates, DNA coding lengths, gene functions, etc. Our findings systematically confirm that disease genes have an intermediate essentiality which is less than housekeeping genes but greater than other human genes.
conclusionThe human genome may contain thousands of essential genes having features which differ significantly from disease and other genes. We propose to classify them as a unique group for comparisons of disease genes with non-disease genes. This new way of classification and comparison enables us to have a clearer understanding of disease genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.