ArticleParticle and fibre toxicology2006
Cytokine expression in mice exposed to diesel exhaust particles by inhalation. Role of tumor necrosis factor.
Article in Particle and fibre toxicology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 63 citations in OpenAlex.
- Pulmonary exposure to renewable diesel exhaust particles alters protein expression and toxicity profiles in bronchoalveolar lavage fluid and plasma of mice.Archives of toxicology · 2025Article
- Pulmonary toxicity assessment of polypropylene, polystyrene, and polyethylene microplastic fragments in mice.Toxicological research · 2024Article
- A review of health effects associated with exposure to jet engine emissions in and around airports.Environmental health : a global access science source · 2021Review
- Particle characterization and toxicity in C57BL/6 mice following instillation of five different diesel exhaust particles designed to differ in physicochemical properties.Particle and fibre toxicology · 2020Article
- Airport emission particles: exposure characterization and toxicity following intratracheal instillation in mice.Particle and fibre toxicology · 2019Article
- Limited developmental neurotoxicity from neonatal inhalation exposure to diesel exhaust particles in C57BL/6 mice.Particle and fibre toxicology · 2019Article
- Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles.BMC genomics · 2018Article
- Particulate Matter Air Pollution: Effects on the Cardiovascular System.Frontiers in endocrinology · 2018Review
- Article
- Occupational exposure to diesel engine exhaust and alterations in immune/inflammatory markers: a cross-sectional molecular epidemiology study in China.Carcinogenesis · 2017Article
- Role of tumor necrosis factor-α and its receptors in diesel exhaust particle-induced pulmonary inflammation.Scientific reports · 2017Article
- Carbon black nanoparticles induce biphasic gene expression changes associated with inflammatory responses in the lungs of C57BL/6 mice following a single intratracheal instillation.Toxicology and applied pharmacology · 2015Article
- DNA damage following pulmonary exposure by instillation to low doses of carbon black (Printex 90) nanoparticles in mice.Environmental and molecular mutagenesis · 2015Article
- Diesel exhaust particle exposure increases severity of allergic asthma in young mice.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2013Article
- Diesel exhaust particle induction of IL-17A contributes to severe asthma.The Journal of allergy and clinical immunology · 2013Article
- Modest effect on plaque progression and vasodilatory function in atherosclerosis-prone mice exposed to nanosized TiO(2).Particle and fibre toxicology · 2011Article
- Pulmonary effects of inhaled diesel exhaust in young and old mice: a pilot project.Research report (Health Effects Institute) · 2010Article
- Comparative effects of inhaled diesel exhaust and ambient fine particles on inflammation, atherosclerosis, and vascular dysfunction.Inhalation toxicology · 2010Article
- Left-sided cardiac valvulitis in tristetraprolin-deficient mice: the role of tumor necrosis factor alpha.The American journal of pathology · 2010Article
- Mouse models to unravel the role of inhaled pollutants on allergic sensitization and airway inflammation.Respiratory research · 2010Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParticulate air pollution has been associated with lung and cardiovascular disease, for which lung inflammation may be a driving mechanism. The pro-inflammatory cytokine, tumor necrosis factor (TNF) has been suggested to have a key-role in particle-induced inflammation.We studied the time course of gene expression of inflammatory markers in the lungs of wild type mice and Tnf-/- mice after exposure to diesel exhaust particles (DEPs). Mice were exposed to either a single or multiple doses of DEP by inhalation. We measured the mRNA level of the cytokines Tnf and interleukin-6 (Il-6) and the chemokines, monocyte chemoattractant protein (Mcp-1), macrophage inflammatory protein-2 (Mip-2) and keratinocyte derived chemokine (Kc) in the lung tissue at different time points after exposure.
resultsTnf mRNA expression levels increased late after DEP-inhalation, whereas the expression levels of Il-6, Mcp-1 and Kc increased early. The expression of Mip-2 was independent of TNF if the dose was above a certain level. The expression levels of the cytokines Kc, Mcp-1 and Il-6, were increased in the absence of TNF.
conclusionOur data demonstrate that Tnf is not important in early DEP induced inflammation and rather exerts negative influence on Mcp-1 and Kc mRNA levels. This suggests that other signalling pathways are important, a candidate being one involving Mcp-1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.