ArticleMalaria journal2006
Therapeutic efficacy test in malaria falciparum in Antioquia, Colombia.
Article in Malaria journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Artemisinin-based combination therapy for treating uncomplicated malaria.The Cochrane database of systematic reviews · 2009Pooled it
- Malaria: uncomplicated, caused by Plasmodium falciparum.BMJ clinical evidence · 2007Pooled it
- Mefloquine pharmacokinetics and mefloquine-artesunate effectiveness in Peruvian patients with uncomplicated Plasmodium falciparum malaria.Malaria journal · 2009Trial
- Artemisinin-based combination therapy for uncomplicated Plasmodium falciparum malaria in Colombia.Malaria journal · 2007Trial
- Modelling an Optimal Climate-Driven Malaria Transmission Control Strategy to Optimise the Management of Malaria in Mberengwa District, Zimbabwe: A Multi-Method Study Protocol.International journal of environmental research and public health · 2025Article
- Genomics of Plasmodium vivax in Colombia reveals evidence of local bottle-necking and inter-country connectivity in the Americas.Scientific reports · 2023Article
- Molecular surveillance for anti-malarial drug resistance and genetic diversity of Plasmodium falciparum after chloroquine and sulfadoxine-pyrimethamine withdrawal in Quibdo, Colombia, 2018.Malaria journal · 2022Article
- Article
- Efficacy of Different Primaquine Regimens to ControlThe American journal of tropical medicine and hygiene · 2017Article
- Longitudinal analysis of Plasmodium falciparum genetic variation in Turbo, Colombia: implications for malaria control and elimination.Malaria journal · 2015Article
- Placental malaria in Colombia: histopathologic findings in Plasmodium vivax and P. falciparum infections.The American journal of tropical medicine and hygiene · 2013Article
- Diosgenone synthesis, anti-malarial activity and QSAR of analogues of this natural product.Molecules (Basel, Switzerland) · 2013Review
- Diagnosis of gestational, congenital, and placental malaria in Colombia: comparison of the efficacy of microscopy, nested polymerase chain reaction, and histopathology.The American journal of tropical medicine and hygiene · 2011Article
- Origin and dissemination across the Colombian Andes mountain range of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum.Antimicrobial agents and chemotherapy · 2010Article
- Article
- Efficacy of amodiaquine/artesunate combination therapy for uncomplicated malaria in children under five years in ghana.Ghana medical journal · 2008Article
- Amodiaquine failure associated with erythrocytic glutathione in Plasmodium falciparum malaria.Malaria journal · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveEvaluate the frequency of failure of eight treatments for non-complicated malaria caused by Plasmodium falciparum in patients from Turbo (Urabá region), El Bagre and Zaragoza (Bajo Cauca region), applying the 1998 protocol of the World Health Organization (WHO). Monotherapies using chloroquine (CQ), amodiaquine (AQ), mefloquine (MQ) and sulphadoxine-pyrimethamine (SP), and combinations using chloroquine-sulphadoxine-pyrimethamine (CQ-SP), amodiaquine-sulphadoxine-pyrimethamine (AQ-SP), mefloquine-sulphadoxine-pyrimethamine (MQ-SP) and artesunate-sulphadoxine-pyrimethamine (AS-SP), were examined. METHODOLOGY: A balanced experimental design with eight groups. Samples were selected based on statistical and epidemiological criteria. Patients were followed for 21 to 28 days, including seven or eight parasitological and clinical evaluations, with an active search for defaulting patients. A non-blinded evaluation of the antimalarial treatment response (early failure, late failure, adequate response) was performed.
resultsInitially, the loss of patients to follow-up was higher than 40%, but the immediate active search for the cases and the monetary help for transportation expenses of patients, reduced the loss to 6%. The treatment failure was: CQ 82%, AQ 30%, MQ 4%, SP 24%, CQ-SP 17%, AQ-SP 2%, MQ-S-P 0%, AS-SP 3%.
conclusionThe characteristics of an optimal epidemiological monitoring system of antimalarial treatment response in Colombia are discussed. It is proposed to focus this on early failure detection, by applying a screening test every two to three years, based on a seven to 14-day follow-up. Clinical and parasitological assessment would be carried out by a general physician and a field microscopist from the local hospital, with active measures to search for defaulter patients at follow-up.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.