ArticleJournal of autoimmune diseases2006
Virus-mediated autoimmunity in Multiple Sclerosis.
Article in Journal of autoimmune diseases, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Risk factors associated with the onset of relapsing-remitting and primary progressive multiple sclerosis: a systematic review.BioMed research international · 2015Pooled it
- Medical software for precision diagnostics of infection with immunoprofiling and artificial intelligence.Journal of translational medicine · 2026Review
- Relevance ofThe Egyptian journal of neurology, psychiatry and neurosurgery · 2018Article
- Viruses and endogenous retroviruses in multiple sclerosis: From correlation to causation.Acta neurologica Scandinavica · 2017Review
- Viruses and Multiple Sclerosis: From Mechanisms and Pathways to Translational Research Opportunities.Molecular neurobiology · 2017Review
- Demyelination in multiple sclerosis.Handbook of clinical neurology · 2014Review
- Infection and autoimmune disease.Rheumatology international · 2012Review
- Epstein-Barr Virus and MS:Causality or Association?International MS journal · 2011Article
- Autoimmunity-related demyelination in infection by Japanese encephalitis virus.Journal of biomedical science · 2011Article
- The cross-reactivity of the enterovirus 71 to human brain tissue and identification of the cross-reactivity related fragments.Virology journal · 2010Article
- T-cell based immunotherapy in experimental autoimmune encephalomyelitis and multiple sclerosis.Immunotherapy · 2010Review
- Toll-like receptors in neurodegeneration.Brain research reviews · 2009Review
- Human RNA "rumor" viruses: the search for novel human retroviruses in chronic disease.Microbiology and molecular biology reviews : MMBR · 2008Review
- Sequential polymicrobial infections lead to CNS inflammatory disease: possible involvement of bystander activation in heterologous immunity.Journal of neuroimmunology · 2007Article
- Evidence for human herpesvirus 6 variant A antibodies in multiple sclerosis: diagnostic and therapeutic implications.Journal of neurovirology · 2007Article
- Review
- The Potential Role of T Helper Cell 22 and IL-22 in Immunopathogenesis of Multiple Sclerosis.Innovations in clinical neuroscienceReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiological data suggest the notion that in Multiple Sclerosis (MS) is an acquired autoimmune disease and the cause may be an environmental factor(s), probably infectious, in genetically susceptible individuals. Several cases of viral induced demyelinatimg encephalomyelitis in human beings and in experimental models as well as the presence of IgG oligoclonal bands in the cerebrospinal fluid indicate that the infectious factor may be viral. However, the absence of a specific virus identification in MS central nervous system may hardly support this notion. On the other hand, the partial response of patients with MS to immunosuppressive and immunomodulatory therapy support the evidence of an autoimmune etiology for MS. However, the autoimmune hypothesis shares the same criticism with the infectious one in that no autoantigen(s) specific to and causative for MS has ever been identified. Nevertheless, the absence of identifiable infectious agent, especially viral does not rule out its presence at a certain time--point and the concomitant long term triggering of an autoimmune cascade of events thereafter. Several concepts have emerged in an attempt to explain the autoimmune mechanisms and ongoing neurodegeneration in MS on the basis of the infectious--viral hypothesis.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.