ArticleBMC cancer2006
HFE H63D mutation frequency shows an increase in Turkish women with breast cancer.
Article in BMC cancer, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- The risk of new-onset cancer associated with HFE C282Y and H63D mutations: evidence from 87,028 participants.Journal of cellular and molecular medicine · 2016Pooled it
- C282Y polymorphism in the HFE gene is associated with risk of breast cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Pooled it
- Hemochromatosis: A Risk Factor for Breast Cancer? Systematic Review and Meta-Analysis.European journal of breast health · 2025Article
- Article
- Impact of HFE variants and sex in lung cancer.PloS one · 2019Article
- The role of HFE genotype in macrophage phenotype.Journal of neuroinflammation · 2018Article
- Beyond Human Leukocyte Antigen Class I Antigens: Hereditary Hemochromatosis Gene Mutations in Recurrent Aphthous Oral Ulcers and Behçet Disease in the South of Tunisia.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2017Article
- Association Studies of HFE C282Y and H63D Variants with Oral Cancer Risk and Iron Homeostasis Among Whites and Blacks.Cancers · 2015Article
- Ancestral association between HLA and HFE H63D and C282Y gene mutations from northwest Colombia.Genetics and molecular biology · 2015Article
- HFE polymorphisms affect survival of brain tumor patients.Journal of neuro-oncology · 2015Article
- Premenopausal plasma ferritin levels, HFE polymorphisms, and risk of breast cancer in the nurses' health study II.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014Article
- Evidence for the Influence of the Iron Regulatory MHC Class I Molecule HFE on Tumor Progression in Experimental Models and Clinical Populations.Translational oncogenomics · 2014Review
- Should we screen for hereditary hemochromatosis in healthy Lebanese: a pilot study.Molecular biology reports · 2012Article
- HFE, MTHFR, and FGFR4 genes polymorphisms and breast cancer in Brazilian women.Molecular and cellular biochemistry · 2011Article
- Impact of hemochromatosis gene (HFE) mutations on epithelial ovarian cancer risk and prognosis.International journal of cancer · 2011Article
- Phenotypic expression of hereditary hemochromatosis: what have we learned from the population studies?Current gastroenterology reports · 2010Review
- Hereditary haemochromatosis gene (HFE) H63D mutation shows an association with abnormal sperm motility.Molecular biology reports · 2009Article
- Red meat consumption during adolescence among premenopausal women and risk of breast cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2008Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe hereditary hemochromatosis gene HFE plays a pivotal role in iron homeostasis. The association between cancer and HFE hetero- or homozygosity has previously been shown including hepatocellular and nonhepatocellular malignancies. This study was performed to compare frequencies of HFE C282Y and H63D variants in Turkish women with breast cancer and healthy controls.
methodsArchived DNA samples of Hacettepe University Oncology Institute were used in this study. The HFE gene was investigated by PCR-RFLP.
resultsAll subjects studied were free from C282Y mutation. Thirty-nine patients had H63D mutation and were all heterozygous. H63D allele frequency was 22.2% (39/176) in the breast cancer patients, and 14% (28/200) in the healthy volunteers. Statistical analysis of cases with HFE H63D phenotype showed significant difference between breast cancer and healthy volunteers (P = 0.02).
conclusionOur results suggest that HFE H63D mutation frequencies were increased in the breast cancer patients in comparison to those in the general population. Also, odds ratios (odds ratio = 2.05) computed in this study suggest that H63D has a positive association with breast cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.