ArticleThe Journal of cell biology1991
Characterization of A 54-kD protein of the inner nuclear membrane: evidence for cell cycle-dependent interaction with the nuclear lamina.
Article in The Journal of cell biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 74 citations in OpenAlex.
- Inner nuclear membrane proteins: impact on human disease.Chromosoma · 2012Review
- Article
- Structural organization of the endoplasmic reticulum.EMBO reports · 2002Review
- A visual screen of a GFP-fusion library identifies a new type of nuclear envelope membrane protein.The Journal of cell biology · 1999Article
- Detergent-salt resistance of LAP2alpha in interphase nuclei and phosphorylation-dependent association with chromosomes early in nuclear assembly implies functions in nuclear structure dynamics.The EMBO journal · 1998Article
- Nuclear membrane vesicle targeting to chromatin in a Drosophila embryo cell-free system.Molecular biology of the cell · 1997Article
- Localization and posttranslational modifications of otefin, a protein required for vesicle attachment to chromatin, during Drosophila melanogaster development.Molecular and cellular biology · 1997Article
- Insertional mutation of the Drosophila nuclear lamin Dm0 gene results in defective nuclear envelopes, clustering of nuclear pore complexes, and accumulation of annulate lamellae.The Journal of cell biology · 1997Article
- The lamin B receptor (LBR) provides essential chromatin docking sites at the nuclear envelope.The EMBO journal · 1996Article
- Targeting of membranes to sea urchin sperm chromatin is mediated by a lamin B receptor-like integral membrane protein.The Journal of cell biology · 1996Article
- M-phase-specific phosphorylation and structural rearrangement of the cytoplasmic cross-linking protein plectin involve p34cdc2 kinase.Molecular biology of the cell · 1996Article
- The MAN antigens are non-lamin constituents of the nuclear lamina in vertebrate cells.Chromosoma · 1996Article
- Signals and structural features involved in integral membrane protein targeting to the inner nuclear membrane.The Journal of cell biology · 1995Article
- Analysis of nuclear lamin isoprenylation in Xenopus oocytes: isoprenylation of lamin B3 precedes its uptake into the nucleus.The Journal of cell biology · 1995Article
- Colocalization of vertebrate lamin B and lamin B receptor (LBR) in nuclear envelopes and in LBR-induced membrane stacks of the yeast Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Type B lamins remain associated with the integral nuclear envelope protein p58 during mitosis: implications for nuclear reassembly.The EMBO journal · 1994Article
- The role of CaaX-dependent modifications in membrane association of Xenopus nuclear lamin B3 during meiosis and the fate of B3 in transfected mitotic cells.The Journal of cell biology · 1993Article
- Multiple regions of NSR1 are sufficient for accumulation of a fusion protein within the nucleolus.The Journal of cell biology · 1993Article
- Membrane-associated lamins in Xenopus egg extracts: identification of two vesicle populations.The Journal of cell biology · 1993Article
- Stepwise reassembly of the nuclear envelope at the end of mitosis.The Journal of cell biology · 1993Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using a mAb (R-7), we have characterized a 54-kD protein of the chicken nuclear envelope. Based on its biochemical properties and subnuclear distribution p54 is likely to be an integral membrane component specific to the inner nuclear membrane. Fractionation experiments indicate that p54 interacts, directly or indirectly, with the nuclear lamina, and analysis of p54 in cultured cells suggests that this interaction is controlled by cell cycle-dependent posttranslational modification, most likely phosphorylation. Modification of p54 results in a slightly reduced electrophoretic mobility, and it converts the protein from a detergent-resistant to a detergent-extractable form. Detergent solubilization of p54 can be induced in vivo by treating isolated nuclei or nuclear envelopes with highly purified cdc2 kinase, one of the most prominent kinases active in mitotic cells. These results suggest that mitotic phosphorylation of p54 might contribute to control nuclear envelope dynamics during mitosis in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.