ArticleBiochemistry2006
Adenosine is inherently favored as the branch-site RNA nucleotide in a structural context that resembles natural RNA splicing.
Article in Biochemistry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Site-Selective Modification and Labeling of Native RNA.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Review
- New Deoxyribozymes for the Native Ligation of RNA.Molecules (Basel, Switzerland) · 2020Article
- Isolation of DNA aptamers for herbicides under varying divalent metal ion concentrations.Aptamers (Oxford, England) · 2018Article
- Debranchase-resistant labeling of RNA using the 10DM24 deoxyribozyme and fluorescent modified nucleotides.Chemical communications (Cambridge, England) · 2017Article
- Mg2+-dependent conformational changes and product release during DNA-catalyzed RNA ligation monitored by Bimane fluorescence.Nucleic acids research · 2015Article
- Enhanced deoxyribozyme-catalyzed RNA ligation in the presence of organic cosolvents.Biopolymers · 2013Article
- Improved deoxyribozymes for synthesis of covalently branched DNA and RNA.Nucleic acids research · 2011Article
- DNA-catalyzed serine side chain reactivity and selectivity.Chemical communications (Cambridge, England) · 2010Article
- Deoxyribozymes: selection design and serendipity in the development of DNA catalysts.Accounts of chemical research · 2009Review
- Use of deoxyribozymes in RNA research.Methods in enzymology · 2009Article
- Convergent and general one-step DNA-catalyzed synthesis of multiply branched DNA.Organic letters · 2008Article
- X-ray structures of U2 snRNA-branchpoint duplexes containing conserved pseudouridines.Biochemistry · 2008Article
- Ty1 reverse transcriptase does not read through the proposed 2',5'-branched retrotransposition intermediate in vitro.RNA (New York, N.Y.) · 2007Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We previously used in vitro selection to identify the 7S11 deoxyribozyme, which catalyzes formation of 2',5'-branched RNA using a branch-site adenosine nucleophile and a 5'-triphosphate electrophile. An unanswered question is whether the use of branch-site adenosine is inherently preferred or a chance event during the particular selection experiment. Here we have found that deoxyribozymes newly selected to use uridine as the branch-site RNA nucleotide in a structural context that resembles natural RNA splicing instead prefer a branch-site adenosine, although adenosine was never available during the selection itself. Our results support a chemical basis for nature's choice of the branch-site nucleotide, which is almost always adenosine in group II introns and the spliceosome.
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Registered trials
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