ArticleEuropean child & adolescent psychiatry2006
Do antidepressants precipitate youth suicide?: a nationwide pharmacoepidemiological study.
Article in European child & adolescent psychiatry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 4 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Risk of Suicidal Behaviors and Antidepressant Exposure Among Children and Adolescents: A Meta-Analysis of Observational Studies.Frontiers in psychiatry · 2022Pooled it
- Pharmacovigilance in children: detecting adverse drug reactions in routine electronic healthcare records. A systematic review.British journal of clinical pharmacology · 2015Pooled it
- Newer generation antidepressants for depressive disorders in children and adolescents.The Cochrane database of systematic reviews · 2012Pooled it
- Selective serotonin reuptake inhibitors and risk of suicide: a systematic review of observational studies.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2009Pooled it
- Antidepressants and the risk of suicide in young persons--prescription trends and toxicological analyses.Acta psychiatrica Scandinavica · 2014Article
- Antidepressant drugs and the risk of suicide in children and adolescents.Paediatric drugs · 2014Review
- Mother's country of birth and prescription of psychotropic medication in Swedish adolescents: a life course approach.BMJ open · 2012Article
- Antidepressants and Suicide Risk: A Comprehensive Overview.Pharmaceuticals (Basel, Switzerland) · 2010Review
- Proper studies of selective serotonin reuptake inhibitors are needed for youth with depression.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2009Article
- Effect of regulatory warnings on antidepressant prescription rates, use of health services and outcomes among children, adolescents and young adults.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2008Article
- Frequency of different anti-depressants associated with suicides and drug deaths.International journal of legal medicine · 2008Article
- Suicide risk in depression and bipolar disorder: Do impulsiveness-aggressiveness and pharmacotherapy predict suicidal intent?Neuropsychiatric disease and treatment · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The association between treatment with Selective serotonin reuptake inhibitors (SSRIs) and suicide in children and adolescents on the individual and ecological level were examined in a nationwide Danish pharmacoepidemiological register-linkage study including all persons aged 10-17 years treated with antidepressants during the period 1995-1999 (n=2,569) and a randomly selected control population (n=50,000). A tripartite approach was used. In Part 1, changes in youth suicide and use of antidepressants were examined. In Part 2, we made an assessment of youth suicide characteristics. In Part 3, we analysed the relative risk (RR) of suicide according to antidepressant treatment corrected for psychiatric hospital contact to minimize the problem of confounding by indication. The use of SSRIs among children and adolescents increased substantially during the study period, but the suicide rate remained stable (Part 1). Among 42 suicides nationally aged 10-17 years at death, none was treated with SSRIs within 2 weeks prior to suicide (Part 2). There was an increased rate of suicide associated with SSRIs (RR=4.47), however, not quite significant (95% CI: 0.95-20.96), when adjusted for severity of illness (Part 3). Conclusively, we were not able to identify an association between treatment with SSRIs and completed suicide among children and adolescents.
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Registered trials
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