ArticleVeterinary research communications2006
Hydroxysteroid dehydrogenases in bovine and porcine granulosa cells convert zearalenone into its hydroxylated metabolites alpha-zearalenol and beta-zearalenol.
Article in Veterinary research communications, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 46 citations in OpenAlex.
- Unveiling a Novel Zearalenone Biodegradation Pathway inInternational journal of molecular sciences · 2025Article
- Effects of Exposure to Low Zearalenone Concentrations Close to the EU Recommended Value on Weaned Piglets' Colon.Toxins · 2023Article
- A critical evaluation of health risk assessment of modified mycotoxins with a special focus on zearalenone.Mycotoxin research · 2019Article
- ModifiedMolecules (Basel, Switzerland) · 2018Review
- Risks for animal health related to the presence of zearalenone and its modified forms in feed.EFSA journal. European Food Safety Authority · 2017Article
- Crocin protects human embryonic kidney cells (HEK293) from α- and β-Zearalenol-induced ER stress and apoptosis.Environmental science and pollution research international · 2016Article
- Determination of zearalenone and its metabolites in endometrial cancer by coupled separation techniques.Analytical and bioanalytical chemistry · 2011Article
- Zearalenone is bioactivated in the river Buffalo (Bubalus bubalis): hepatic biotransformation.Tropical animal health and production · 2010Article
- Zearalenone and reproductive function in farm animals.International journal of molecular sciences · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The enzymes 3alpha- and 3beta-hydroxysteroid dehydrogenase (3alpha- and 3beta-HSD) play a pivotal role in synthesis of various steroid hormones including oestradiol and testosterone. The structure of the mycotoxin zearalenone resembles many characteristics of steroids and binds to oestrogen receptors as an agonist. Consequently, it is suggested that zearalenone is also a substrate for 3alpha-HSD and 3beta-HSD. 3alpha-HSD and 3beta-HSD isoforms are expressed in the liver and kidney but also in many steroidogenic tissues. It was the aim of the present study to demonstrate the presence of these enzymes in granulosa cells, which were obtained from bovine and porcine ovaries, and to investigate whether zearalenone is a substrate for these enzymes. The results show a species-specific expression pattern in the granulosa cells of both species. Moreover, it was demonstrated that zearalenone when added to the culture medium, is converted into alpha-zearalenol and beta-zearalenol. Corresponding to the apparent expression profile, in porcine granulosa cells predominantly alpha-zearalenol was formed, whereas bovine granulosa cells preferentially converted zearalenone into beta-zearalenol. This is the first report demonstrating the extrahepatic biotransformation of zearalenone in target tissues.
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