ArticleJournal of virology2006
Identification of mutations causing temperature-sensitive defects in Semliki Forest virus RNA synthesis.
Article in Journal of virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Alphavirus nsP2: A Multifunctional Regulator of Viral Replication and Promising Target for Anti-Alphavirus Therapies.Reviews in medical virology · 2025Review
- Distinct chikungunya virus polymerase palm subdomains contribute to viral protein accumulation and virion production.PLoS pathogens · 2024Article
- Molecular Virology of Chikungunya Virus.Current topics in microbiology and immunology · 2022Review
- Timeliness of Proteolytic Events Is Prerequisite for Efficient Functioning of the Alphaviral Replicase.Journal of virology · 2018Article
- Obatoclax Inhibits Alphavirus Membrane Fusion by Neutralizing the Acidic Environment of Endocytic Compartments.Antimicrobial agents and chemotherapy · 2017Article
- Discovery of a novel compound with anti-venezuelan equine encephalitis virus activity that targets the nonstructural protein 2.PLoS pathogens · 2014Article
- Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays.PloS one · 2011Article
- Neurons and oligodendrocytes in the mouse brain differ in their ability to replicate Semliki Forest virus.Journal of neurovirology · 2009Article
- Molecular defects caused by temperature-sensitive mutations in Semliki Forest virus nsP1.Journal of virology · 2008Article
- Properties of non-structural protein 1 of Semliki Forest virus and its interference with virus replication.The Journal of general virology · 2008Article
- Enzymatic defects of the nsP2 proteins of Semliki Forest virus temperature-sensitive mutants.Journal of virology · 2007Article
- Characterization of the cysteine protease domain of Semliki Forest virus replicase protein nsP2 by in vitro mutagenesis.FEBS letters · 2006Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
We have sequenced the nonstructural protein coding region of Semliki Forest virus temperature-sensitive (ts) mutant strains ts1, ts6, ts9, ts10, ts11, ts13, and ts14. In each case, the individual amino acid changes uncovered were transferred to the prototype strain background and thereby identified as the underlying cause of the altered RNA synthesis phenotype. All mutations mapping to the protease domain of nonstructural protein nsP2 caused defects in nonstructural polyprotein processing and subgenomic RNA synthesis, and all mutations in the helicase domain of nsP2 affected subgenomic RNA production. These types of defects were not associated with mutations in other nonstructural proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.