ArticleProceedings of the National Academy of Sciences of the United States of America2006
Checkpoint functions are required for normal S-phase progression in Saccharomyces cerevisiae RCAF- and CAF-I-defective mutants.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Chromatin assembly factor-1 preserves genome stability inCell stress · 2023Article
- Pathways and Mechanisms that Prevent Genome Instability inGenetics · 2017Review
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- Histone chaperone CAF-1: essential roles in multi-cellular organism development.Cellular and molecular life sciences : CMLS · 2015Review
- H2B mono-ubiquitylation facilitates fork stalling and recovery during replication stress by coordinating Rad53 activation and chromatin assembly.PLoS genetics · 2014Article
- A saccharomyces cerevisiae RNase H2 interaction network functions to suppress genome instability.Molecular and cellular biology · 2014Article
- Systematic triple-mutant analysis uncovers functional connectivity between pathways involved in chromosome regulation.Cell reports · 2013Article
- Nucleosome assembly and genome integrity: The fork is the link.Bioarchitecture · 2012Article
- Rapid analysis of Saccharomyces cerevisiae genome rearrangements by multiplex ligation-dependent probe amplification.PLoS genetics · 2012Article
- Histone H3K56 acetylation, CAF1, and Rtt106 coordinate nucleosome assembly and stability of advancing replication forks.PLoS genetics · 2011Article
- Genome stability control by checkpoint regulation of tRNA gene transcription.Transcription · 2010Article
- Replication stress checkpoint signaling controls tRNA gene transcription.Nature structural & molecular biology · 2010Article
- The Saccharomyces cerevisiae Rad6 postreplication repair and Siz1/Srs2 homologous recombination-inhibiting pathways process DNA damage that arises in asf1 mutants.Molecular and cellular biology · 2009Article
- Chromatin assembly factors Asf1 and CAF-1 have overlapping roles in deactivating the DNA damage checkpoint when DNA repair is complete.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Smc5-Smc6 complex suppresses gross chromosomal rearrangements mediated by break-induced replications.DNA repair · 2008Article
- ATM-mediated transcriptional and developmental responses to gamma-rays in Arabidopsis.PloS one · 2007Article
- Mutual interdependence of MSI1 (CAC3) and YAK1 in Saccharomyces cerevisiae.Journal of molecular biology · 2007Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The chromatin-assembly factor I (CAF-I) and the replication-coupling assembly factor (RCAF) complexes function in chromatin assembly during DNA replication and repair and play a role in the maintenance of genome stability. Here, we have investigated their role in checkpoints and S-phase progression. FACS analysis of mutants lacking Asf1 or Cac1 as well as various checkpoint proteins indicated that normal rates of S-phase progression in asf1 mutants have a strong requirement for replication checkpoint proteins, whereas normal S-phase progression in cac1 mutants has only a weak requirement for either replication or DNA-damage checkpoint proteins. Furthermore, asf1 mutants had high levels of Ddc2.GFP foci that were further increased in asf1 dun1 double mutants consistent with a requirement for checkpoint proteins in S-phase progression in asf1 mutants, whereas cac1 mutants had much lower levels of Ddc2.GFP foci that were not increased by a dun1 mutation. Our data suggest that RCAF defects lead to unstable replication forks that are then stabilized by replication checkpoint proteins, whereas CAF-I defects likely cause different types of DNA damage.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.