ArticleBiophysical journal2006
Cellular responses to substrate topography: role of myosin II and focal adhesion kinase.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 189 citations in OpenAlex.
- Collagen fiber density observed in metastatic ovarian cancer promotes tumor cell adhesion.Acta biomaterialia · 2025Article
- The Effects of Biomimetic Surface Topography on Vascular Cells: Implications for Vascular Conduits.Advanced healthcare materials · 2024Review
- Biomimetic Hydrogel Strategies for Cancer Therapy.Gels (Basel, Switzerland) · 2024Review
- Unveiling the superior function of RADA in bone regeneration compared to KSL as two critical cores within self-assembling peptide nanofibers: Insights from in vitro and in vivo studies.Regenerative therapy · 2024Article
- From stress fiber to focal adhesion: a role of actin crosslinkers in force transmission.Frontiers in cell and developmental biology · 2024Review
- Ameboid cell migration through regular arrays of micropillars under confinement.Biophysical journal · 2022Article
- Gaussian curvature-driven direction of cell fate toward osteogenesis with triply periodic minimal surface scaffolds.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Contact guidance as a consequence of coupled morphological evolution and motility of adherent cells.Biomechanics and modeling in mechanobiology · 2022Article
- Anisotropic scaffolds for peripheral nerve and spinal cord regeneration.Bioactive materials · 2021Review
- The effects of surface topography modification on hydrogel properties.APL bioengineering · 2021Review
- Cell Type-Specific Adhesion and Migration on Laser-Structured Opaque Surfaces.International journal of molecular sciences · 2020Article
- Polystyrene Topography Sticker Array for Cell-Based Assays.Recent progress in materials · 2020Article
- Cellular and Subcellular Contact Guidance on Microfabricated Substrates.Frontiers in bioengineering and biotechnology · 2020Review
- Review
- Article
- Motile Dendritic Cells Sense and Respond to Substrate Geometry.Annals of biomedical engineering · 2018Article
- Magneto-active substrates for local mechanical stimulation of living cells.Scientific reports · 2018Article
- Microgroove and Collagen-poly(ε-caprolactone) Nanofiber Mesh Coating Improves the Mechanical Stability and Osseointegration of Titanium Implants.Nanomaterials (Basel, Switzerland) · 2017Article
- Contact guidance requires spatial control of leading-edge protrusion.Molecular biology of the cell · 2017Article
- Intermediate filament reorganization dynamically influences cancer cell alignment and migration.Scientific reports · 2017Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Although two-dimensional cultures have been used extensively in cell biological research, most cells in vivo exist in a three-dimensional environment with complex topographical features, which may account for at least part of the striking differences between cells grown in vivo and in vitro. To investigate how substrate topography affects cell shape and movement, we plated fibroblasts on chemically identical polystyrene substrates with either flat surfaces or micron-sized pillars. Compared to cells on flat surfaces, 3T3 cells on pillar substrates showed a more branched shape, an increased linear speed, and a decreased directional stability. These responses may be attributed to stabilization of cell adhesion on pillars coupled to myosin II-dependent contractions toward pillars. Moreover, using FAK-/- fibroblasts we showed that focal adhesion kinase, or FAK, is essential for the responses to substrate topography. We propose that increased surface contact provided by topographic features guides cell migration by regulating the strength of local adhesions and contractions, through a FAK- and myosin II-dependent mechanism.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.